The effect of specific modifications of the amine ligands on the solubility, stability, CO release to myoglobin and whole blood, cell toxicity and haemolytic index of [Mo(CO)4(NR3)2] complexes

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

A series of cis-[Mo(CO)4(amine)2] complexes (NR 3 = morpholine 1; 4-Me-piperazine, 2; H2NCH 2CH2NH2, 3; H2NCH2CH 2-morpholine (4) R2NCH2CH2- piperazine-4-Me (R = H, 5); R = Me, 6); Me2NCH2CH 2NMe2, 7) was prepared in good yields, in a one-step microwave-assisted synthesis. The X-ray diffraction structures of the complexes 4, 5 and 6 are reported. The stability of the complexes 1-7 in aqueous, aerobic media was studied by UV-Vis spectrophotometry, RP-HPLC and gas chromatography at several pH values. Stability beyond 1 h requires bidentate ligands with at least one tertiary amine ligand and increases in the order 4 <5 <6. Stability is approximately the same at pH 7.5 and pH 3.9 for 5 and 6 in solutions acidified with HCl. Acidification with CF3COOH induces decomposition. The order of CO transfer rate to deoxy-Mb and haemoglobin in whole blood is 1 > 2 > 3 > 4 > 5 > 6 >> 7, but it is much faster to whole blood. The haemolytic index of some compounds increases in a similar order: 1 <2 <5 <6; with the exception of 1, the complexes are not toxic to RAW264.7 cells up to a concentration of 100 μM.

Original languageEnglish
Pages (from-to)89-100
Number of pages12
JournalJournal Of Organometallic Chemistry
Volume760
DOIs
Publication statusPublished - 15 Jun 2014

Keywords

  • CO releasing molecules
  • CORM
  • Molybdenum carbonyl

Fingerprint

Dive into the research topics of 'The effect of specific modifications of the amine ligands on the solubility, stability, CO release to myoglobin and whole blood, cell toxicity and haemolytic index of [Mo(CO)<sub>4</sub>(NR<sub>3</sub>)<sub>2</sub>] complexes'. Together they form a unique fingerprint.

Cite this