The dual function of flavodiiron proteins: Oxygen and/or nitric oxide reductases

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33 Citations (Scopus)

Abstract

Flavodiiron proteins have emerged in the last two decades as a newly discovered family of oxygen and/or nitric oxide reductases widespread in the three life domains, and present in both aerobic and anaerobic organisms. Herein we present the main features of these fascinating enzymes, with a particular emphasis on the metal sites, as more appropriate for this special issue in memory of the exceptional bioinorganic scientist R. J. P. Williams who pioneered the notion of (metal) element availability-driven evolution. We also compare the flavodiiron proteins with the other oxygen and nitric oxide reductases known until now, highlighting how throughout evolution Nature arrived at different solutions for similar functions, in some cases adding extra features, such as energy conservation. These enzymes are an example of the (bioinorganic) unpredictable diversity of the living world.

Original languageEnglish
Pages (from-to)39-52
Number of pages14
JournalJournal Of Biological Inorganic Chemistry
Volume21
Issue number1
DOIs
Publication statusPublished - 1 Mar 2016

Keywords

  • Diiron
  • Flavodiiron
  • Nitric oxide
  • Oxygen
  • Reactive oxygen species

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