The colostrum proteome, ruminant nutrition and immunity: A review

Lorenzo E. Hernández-Castellano, Andrè M. Almeida, Noemi Castro, Anastasio Argüello

Research output: Contribution to journalReview articlepeer-review

66 Citations (Scopus)


In this review authors address colostrum proteins implications in different domestic ruminant species. The colostrogenesis process and how different factors, such as litter size or nutrition during gestation can alter the different components concentrations in colostrum are also reviewed. The different colostrum fractions will be described, focusing on high and low abundant proteins. This review describes the major function of such proteins and their role on the passive immune transfer and nutrition in the newborn animal. It will be also performed a comprehensive review on different techniques and commercial kits available for high abundant protein depletion in colostrum. We will finally focus on how proteomics has been used to address this issue and how it can contribute to the major questions about colostrum associated immunology.

Original languageEnglish
Pages (from-to)64-74
Number of pages11
JournalCurrent Protein and Peptide Science
Issue number1
Publication statusPublished - 2014


  • Colostrum
  • Depletion
  • Immune system
  • Low abundant proteins
  • Proteomics


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