The clinical use of exhaled nitric oxide in wheezing children

Pedro Carreiro Martins, Iolanda Caires, José Rosado Pinto, Pedro Lopes Mata, Simões Torres, Joana Valente, Nuno Neuparth

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


The body of published work on the role of exhaled nitric oxide (FE(NO)) in the study of bronchial inflammation allows it to be classed as a simple, non-invasive measurement that is very useful in evaluating asthmatic patients. During a prospective study into the effects of air pollution on the health of the population of Viseu (Saud'AR Project), children with a clinical history of wheezing were identified through using the International Study of Asthma and Allergy in Childhood (ISAAC) questionnaire. Children later filled in a new standardised questionnaire and underwent skin-prick-tests, spirometry and FE(NO) measurement. Their mean age was 7.8 +/- 1.1 years. Comparing those who wheezed in the 6 months before evaluation (n=27) with those who didn't, statistical differences for Delta FEVI (8% median versus 4.5%, p=0.0399) and for FE(NO) (23 ppb median versus 12 ppb, p=0.0195, respectively) were observed. Concerning children who needed a bronchodilator in the six previous months (n=19) and those who didn't, there was also a statistically significant difference in FE(NO): 27 ppb median versus 11 ppb median, respectively; p<0.0001. When comparing children who needed an unscheduled medical appointment in the six months previous to the evaluation (n=9) and those who didn't, there was also significant differences for FE(NO): 28 ppb median versus 13 ppb median, p=0.0029. In conclusion, the existence of symptoms seems to be better related to FE(NO) than spirometry.
Original languageEnglish
Pages (from-to)195-218
JournalRevista Portuguesa de Pneumologia
Issue number2
Publication statusPublished - 1 Jan 2008


Dive into the research topics of 'The clinical use of exhaled nitric oxide in wheezing children'. Together they form a unique fingerprint.

Cite this