The Charlson age comorbidity index predicts early mortality after surgery for pancreatic cancer

Daniela Dias-Santos; C.R. Ferrone; H. Zheng; K.D. Lillemoe; C. Fernández-Del Castillo

doi:10.1016/j.surg.2014.12.006

The Charlson age comorbidity index predicts early mortality after surgery for pancreatic cancer

Daniela Dias-Santos, C.R. Ferrone, H. Zheng, K.D. Lillemoe, C. Fernández-Del Castillo

NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

Research output: Contribution to journal › Article › peer-review

89 Citations (Scopus)

Abstract

Background Although operative resection represents the only hope for cure in pancreatic cancer, it is associated with significant morbidity and mortality. Furthermore, in some patients disease progression occurs very early postoperatively and no tangible benefit is seen from the operation. Identification of preoperative predictors of death within the first year of surgery could help in the counseling of patients diagnosed with pancreatic cancer. Methods We studied retrospectively patients who underwent resection for pancreatic adenocarcinoma from 2002 to 2012. We calculated the age-adjusted Charlson Age Comorbidity Index (CACI) and used logistic regression models to determine predictors of mortality within 1 year of surgery. Kaplan-Meier curves and Cox proportional hazards models were developed to determine hazard ratios on survival. Results Surgery with curative intent was performed in 497 patients; 136 (27%) died within the first year. A CACI score of >4 was predictive of increased duration of stay (P

Original language	English
Pages (from-to)	881-887
Number of pages	7
Journal	Surgery
Volume	157
Issue number	5
DOIs	https://doi.org/10.1016/j.surg.2014.12.006
Publication status	Published - 2015

Keywords

gemcitabine
adolescent
adult
aged
Article
cancer mortality
cancer surgery
cancer survival
Charlson Age Comorbidity Index
Charlson Comorbidity Index
chemoradiotherapy
child
female
hazard ratio
human
Kaplan Meier method
major clinical study
male
pancreas adenocarcinoma
pancreas resection
pancreaticoduodenectomy
postoperative complication
prediction
priority journal
proportional hazards model
retrospective study
treatment duration
adenocarcinoma
comorbidity
epidemiology
health status indicator
middle aged
mortality
Pancreatic Neoplasms
risk assessment
United States
very elderly
Adenocarcinoma
Adult
Aged
Aged, 80 and over
Comorbidity
Female
Health Status Indicators
Humans
Male
Massachusetts
Middle Aged
Retrospective Studies
Risk Assessment

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.surg.2014.12.006

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title = "The Charlson age comorbidity index predicts early mortality after surgery for pancreatic cancer",

abstract = "Background Although operative resection represents the only hope for cure in pancreatic cancer, it is associated with significant morbidity and mortality. Furthermore, in some patients disease progression occurs very early postoperatively and no tangible benefit is seen from the operation. Identification of preoperative predictors of death within the first year of surgery could help in the counseling of patients diagnosed with pancreatic cancer. Methods We studied retrospectively patients who underwent resection for pancreatic adenocarcinoma from 2002 to 2012. We calculated the age-adjusted Charlson Age Comorbidity Index (CACI) and used logistic regression models to determine predictors of mortality within 1 year of surgery. Kaplan-Meier curves and Cox proportional hazards models were developed to determine hazard ratios on survival. Results Surgery with curative intent was performed in 497 patients; 136 (27%) died within the first year. A CACI score of >4 was predictive of increased duration of stay (P ",

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author = "Daniela Dias-Santos and C.R. Ferrone and H. Zheng and K.D. Lillemoe and {Fern{\'a}ndez-Del Castillo}, C.",

year = "2015",

doi = "10.1016/j.surg.2014.12.006",

language = "English",

volume = "157",

pages = "881--887",

journal = "Surgery",

issn = "0039-6060",

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T1 - The Charlson age comorbidity index predicts early mortality after surgery for pancreatic cancer

AU - Dias-Santos, Daniela

AU - Ferrone, C.R.

AU - Zheng, H.

AU - Lillemoe, K.D.

AU - Fernández-Del Castillo, C.

PY - 2015

Y1 - 2015

N2 - Background Although operative resection represents the only hope for cure in pancreatic cancer, it is associated with significant morbidity and mortality. Furthermore, in some patients disease progression occurs very early postoperatively and no tangible benefit is seen from the operation. Identification of preoperative predictors of death within the first year of surgery could help in the counseling of patients diagnosed with pancreatic cancer. Methods We studied retrospectively patients who underwent resection for pancreatic adenocarcinoma from 2002 to 2012. We calculated the age-adjusted Charlson Age Comorbidity Index (CACI) and used logistic regression models to determine predictors of mortality within 1 year of surgery. Kaplan-Meier curves and Cox proportional hazards models were developed to determine hazard ratios on survival. Results Surgery with curative intent was performed in 497 patients; 136 (27%) died within the first year. A CACI score of >4 was predictive of increased duration of stay (P

AB - Background Although operative resection represents the only hope for cure in pancreatic cancer, it is associated with significant morbidity and mortality. Furthermore, in some patients disease progression occurs very early postoperatively and no tangible benefit is seen from the operation. Identification of preoperative predictors of death within the first year of surgery could help in the counseling of patients diagnosed with pancreatic cancer. Methods We studied retrospectively patients who underwent resection for pancreatic adenocarcinoma from 2002 to 2012. We calculated the age-adjusted Charlson Age Comorbidity Index (CACI) and used logistic regression models to determine predictors of mortality within 1 year of surgery. Kaplan-Meier curves and Cox proportional hazards models were developed to determine hazard ratios on survival. Results Surgery with curative intent was performed in 497 patients; 136 (27%) died within the first year. A CACI score of >4 was predictive of increased duration of stay (P

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The Charlson age comorbidity index predicts early mortality after surgery for pancreatic cancer

Abstract

Keywords

UN SDGs

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