The Charlson age comorbidity index predicts early mortality after surgery for pancreatic cancer

Daniela Dias-Santos, C.R. Ferrone, H. Zheng, K.D. Lillemoe, C. Fernández-Del Castillo

Research output: Contribution to journalArticlepeer-review

74 Citations (Scopus)


Background Although operative resection represents the only hope for cure in pancreatic cancer, it is associated with significant morbidity and mortality. Furthermore, in some patients disease progression occurs very early postoperatively and no tangible benefit is seen from the operation. Identification of preoperative predictors of death within the first year of surgery could help in the counseling of patients diagnosed with pancreatic cancer. Methods We studied retrospectively patients who underwent resection for pancreatic adenocarcinoma from 2002 to 2012. We calculated the age-adjusted Charlson Age Comorbidity Index (CACI) and used logistic regression models to determine predictors of mortality within 1 year of surgery. Kaplan-Meier curves and Cox proportional hazards models were developed to determine hazard ratios on survival. Results Surgery with curative intent was performed in 497 patients; 136 (27%) died within the first year. A CACI score of >4 was predictive of increased duration of stay (P
Original languageEnglish
Pages (from-to)881-887
Number of pages7
Issue number5
Publication statusPublished - 2015


  • gemcitabine
  • adolescent
  • adult
  • aged
  • Article
  • cancer mortality
  • cancer surgery
  • cancer survival
  • Charlson Age Comorbidity Index
  • Charlson Comorbidity Index
  • chemoradiotherapy
  • child
  • female
  • hazard ratio
  • human
  • Kaplan Meier method
  • major clinical study
  • male
  • pancreas adenocarcinoma
  • pancreas resection
  • pancreaticoduodenectomy
  • postoperative complication
  • prediction
  • priority journal
  • proportional hazards model
  • retrospective study
  • treatment duration
  • adenocarcinoma
  • comorbidity
  • epidemiology
  • health status indicator
  • middle aged
  • mortality
  • Pancreatic Neoplasms
  • risk assessment
  • United States
  • very elderly
  • Adenocarcinoma
  • Adult
  • Aged
  • Aged, 80 and over
  • Comorbidity
  • Female
  • Health Status Indicators
  • Humans
  • Male
  • Massachusetts
  • Middle Aged
  • Retrospective Studies
  • Risk Assessment


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