The Carotid Body Does Not Mediate the Acute Ventilatory Effects of Leptin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Citations (Scopus)

Abstract

Leptin is a hormone produced mostly in adipose tissue and playing a key role in the control of feeding and energy expenditure aiming to maintain a balance between food intake and metabolic activity. In recent years, it has been described that leptin might also contributes to control ventilation as the administration of the hormone reverses the hypoxia and hypercapnia commonly encountered in ob/ob mice which show absence of the functional hormone. In addition, it has been shown that the carotid body (CB) of the rat expresses leptin as well as the functional leptin-B receptor. Therefore, the possibility exists that the ventilatory effects of leptin are mediated by the CB chemoreceptors. In the experiments described below we confirm the stimulatory effect of leptin on ventilation, finding additionally that the CB does not mediate the instant to instant control of ventilation.
Original languageUnknown
Title of host publicationAdvances in Experimental Medicine and Biology
EditorsC Peers, P Kumar, C Wyatt, E Gauda, C Nurse, N Prabhakar
Place of PublicationHEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
PublisherSPRINGER-VERLAG BERLIN
Pages379-385
Volume860
ISBN (Print)978-3-319-18440-1; 978-3-319-18439-5
DOIs
Publication statusPublished - 1 Jan 2015
Event18th Meeting of the International-Society-for-Arterial-Chemoreception -
Duration: 1 Jan 2014 → …

Conference

Conference18th Meeting of the International-Society-for-Arterial-Chemoreception
Period1/01/14 → …

Cite this

Conde, S. M. V. S., & Ribeiro, M. J. R. F. (2015). The Carotid Body Does Not Mediate the Acute Ventilatory Effects of Leptin. In C. Peers, P. Kumar, C. Wyatt, E. Gauda, C. Nurse, & N. Prabhakar (Eds.), Advances in Experimental Medicine and Biology (Vol. 860, pp. 379-385). HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY: SPRINGER-VERLAG BERLIN. https://doi.org/10.1007/978-3-319-18440-1\_43