The Bacterial Counterparts of the Eukaryotic Exosome: An Evolutionary Perspective

Research output: Contribution to journalArticlepeer-review


There are striking similarities between the processes of RNA degradation in bacteria and eukaryotes, which rely on the same basic set of enzymatic activities. In particular, enzymes that catalyze 3'→5' RNA decay share evolutionary relationships across the three domains of life. Over the years, a large body of biochemical and structural data has been generated that elucidated the mechanism of action of these enzymes. In this overview, to trace the evolutionary origins of the multisubunit RNA exosome complex, we compare the structural and functional characteristics of the eukaryotic and prokaryotic exoribonucleolytic activities.

Original languageEnglish
Pages (from-to)37-46
Number of pages10
JournalMethods In Molecular Biology (Clifton, N.J.)
Publication statusPublished - 1 Jan 2020


  • 3′→5′ exoribonuclease
  • Dis3
  • Dis3L1
  • PNPase
  • RNase II
  • RNase R


Dive into the research topics of 'The Bacterial Counterparts of the Eukaryotic Exosome: An Evolutionary Perspective'. Together they form a unique fingerprint.

Cite this