The association of fasting plasma sulfur-containing compounds with BMI, serum lipids and apolipoproteins

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Abstract

Background and aim: Sulfur amino acids are recognized as potent modulators of lipid metabolism. Plasma total cysteine (tCys) is associated with fat mass, obesity and serum LDL-cholesterol and apolipoprotein (Apo)-B in large population studies. It is not known how fasting plasma concentrations of cysteine precursors and products relate to these associations in humans, given that sulfur-containing compounds (SCC) influence rodent weight gain and serum lipids. Methods and results: We investigated the cross-sectional associations of fasting plasma SCC (methionine, total homocysteine, cystathionine, tCys, taurine and total glutathione) with BMI and fasting serum lipids and apolipoproteins in 854 men and women with and without cardiovascular disease (CVD). In multiple linear regression analysis adjusted for age, gender, CVD and other SCC, neither methionine, taurine, nor total glutathione was associated with BMI. Plasma taurine was, however, inversely related to HDL-cholesterol (partial r = -0.12, p = 0.004) and its associated apoA1 (partial r = -0.18, p < 0.001). Plasma cystathionine correlated positively with triglycerides and BMI, while tCys positively correlated with total cholesterol, LDL-cholesterol (partial r = 0.20, p < 0.001) and its associated apoB. The associations of SCC with serum lipids were independent of BMI. tCys was also independently associated with BMI (partial r = 0.20, p < 0.001) after adjustment for other SCC, glucose, lipids and apolipoproteins. Conclusions: Fasting tCys is associated with BMI independently of metabolically related SCC. Elevation of plasma SCC is generally associated with an unfavorable lipid profile. The negative relations of plasma taurine with HDL-C and apoA1 deserve further investigation. (C) 2011 Elsevier B.V. All rights reserved.
Original languageUnknown
Pages (from-to)1031-1038
JournalNutrition Metabolism And Cardiovascular Diseases
Volume22
Issue number12
DOIs
Publication statusPublished - 1 Jan 2012

Cite this

@article{a1da944515044c1d94b8b3b26effbf72,
title = "The association of fasting plasma sulfur-containing compounds with BMI, serum lipids and apolipoproteins",
abstract = "Background and aim: Sulfur amino acids are recognized as potent modulators of lipid metabolism. Plasma total cysteine (tCys) is associated with fat mass, obesity and serum LDL-cholesterol and apolipoprotein (Apo)-B in large population studies. It is not known how fasting plasma concentrations of cysteine precursors and products relate to these associations in humans, given that sulfur-containing compounds (SCC) influence rodent weight gain and serum lipids. Methods and results: We investigated the cross-sectional associations of fasting plasma SCC (methionine, total homocysteine, cystathionine, tCys, taurine and total glutathione) with BMI and fasting serum lipids and apolipoproteins in 854 men and women with and without cardiovascular disease (CVD). In multiple linear regression analysis adjusted for age, gender, CVD and other SCC, neither methionine, taurine, nor total glutathione was associated with BMI. Plasma taurine was, however, inversely related to HDL-cholesterol (partial r = -0.12, p = 0.004) and its associated apoA1 (partial r = -0.18, p < 0.001). Plasma cystathionine correlated positively with triglycerides and BMI, while tCys positively correlated with total cholesterol, LDL-cholesterol (partial r = 0.20, p < 0.001) and its associated apoB. The associations of SCC with serum lipids were independent of BMI. tCys was also independently associated with BMI (partial r = 0.20, p < 0.001) after adjustment for other SCC, glucose, lipids and apolipoproteins. Conclusions: Fasting tCys is associated with BMI independently of metabolically related SCC. Elevation of plasma SCC is generally associated with an unfavorable lipid profile. The negative relations of plasma taurine with HDL-C and apoA1 deserve further investigation. (C) 2011 Elsevier B.V. All rights reserved.",
keywords = "GAMMA-GLUTAMYL-TRANSFERASE, CONCERTED ACTION PROJECT, METHIONINE RESTRICTION, VASCULAR-DISEASE, Glutathione, Taurine, Cysteine, Sulfur amino acids, Apolipoproteins, BMI, Serum lipids, HORDALAND HOMOCYSTEINE, METABOLIC SYNDROME, AMINO-ACID, LIVER CHOLESTEROL CONCENTRATIONS, DIETARY TAURINE SUPPLEMENTATION, TOTAL CYSTEINE, Methionine",
author = "Reis, {Roberto Jos{\'e} Palma dos}",
year = "2012",
month = "1",
day = "1",
doi = "10.1016/j.numecd.2011.01.008",
language = "Unknown",
volume = "22",
pages = "1031--1038",
journal = "Nutrition Metabolism And Cardiovascular Diseases",
issn = "0939-4753",
publisher = "Elsevier Science B.V., Amsterdam.",
number = "12",

}

TY - JOUR

T1 - The association of fasting plasma sulfur-containing compounds with BMI, serum lipids and apolipoproteins

AU - Reis, Roberto José Palma dos

PY - 2012/1/1

Y1 - 2012/1/1

N2 - Background and aim: Sulfur amino acids are recognized as potent modulators of lipid metabolism. Plasma total cysteine (tCys) is associated with fat mass, obesity and serum LDL-cholesterol and apolipoprotein (Apo)-B in large population studies. It is not known how fasting plasma concentrations of cysteine precursors and products relate to these associations in humans, given that sulfur-containing compounds (SCC) influence rodent weight gain and serum lipids. Methods and results: We investigated the cross-sectional associations of fasting plasma SCC (methionine, total homocysteine, cystathionine, tCys, taurine and total glutathione) with BMI and fasting serum lipids and apolipoproteins in 854 men and women with and without cardiovascular disease (CVD). In multiple linear regression analysis adjusted for age, gender, CVD and other SCC, neither methionine, taurine, nor total glutathione was associated with BMI. Plasma taurine was, however, inversely related to HDL-cholesterol (partial r = -0.12, p = 0.004) and its associated apoA1 (partial r = -0.18, p < 0.001). Plasma cystathionine correlated positively with triglycerides and BMI, while tCys positively correlated with total cholesterol, LDL-cholesterol (partial r = 0.20, p < 0.001) and its associated apoB. The associations of SCC with serum lipids were independent of BMI. tCys was also independently associated with BMI (partial r = 0.20, p < 0.001) after adjustment for other SCC, glucose, lipids and apolipoproteins. Conclusions: Fasting tCys is associated with BMI independently of metabolically related SCC. Elevation of plasma SCC is generally associated with an unfavorable lipid profile. The negative relations of plasma taurine with HDL-C and apoA1 deserve further investigation. (C) 2011 Elsevier B.V. All rights reserved.

AB - Background and aim: Sulfur amino acids are recognized as potent modulators of lipid metabolism. Plasma total cysteine (tCys) is associated with fat mass, obesity and serum LDL-cholesterol and apolipoprotein (Apo)-B in large population studies. It is not known how fasting plasma concentrations of cysteine precursors and products relate to these associations in humans, given that sulfur-containing compounds (SCC) influence rodent weight gain and serum lipids. Methods and results: We investigated the cross-sectional associations of fasting plasma SCC (methionine, total homocysteine, cystathionine, tCys, taurine and total glutathione) with BMI and fasting serum lipids and apolipoproteins in 854 men and women with and without cardiovascular disease (CVD). In multiple linear regression analysis adjusted for age, gender, CVD and other SCC, neither methionine, taurine, nor total glutathione was associated with BMI. Plasma taurine was, however, inversely related to HDL-cholesterol (partial r = -0.12, p = 0.004) and its associated apoA1 (partial r = -0.18, p < 0.001). Plasma cystathionine correlated positively with triglycerides and BMI, while tCys positively correlated with total cholesterol, LDL-cholesterol (partial r = 0.20, p < 0.001) and its associated apoB. The associations of SCC with serum lipids were independent of BMI. tCys was also independently associated with BMI (partial r = 0.20, p < 0.001) after adjustment for other SCC, glucose, lipids and apolipoproteins. Conclusions: Fasting tCys is associated with BMI independently of metabolically related SCC. Elevation of plasma SCC is generally associated with an unfavorable lipid profile. The negative relations of plasma taurine with HDL-C and apoA1 deserve further investigation. (C) 2011 Elsevier B.V. All rights reserved.

KW - GAMMA-GLUTAMYL-TRANSFERASE

KW - CONCERTED ACTION PROJECT

KW - METHIONINE RESTRICTION

KW - VASCULAR-DISEASE

KW - Glutathione

KW - Taurine

KW - Cysteine

KW - Sulfur amino acids

KW - Apolipoproteins

KW - BMI

KW - Serum lipids

KW - HORDALAND HOMOCYSTEINE

KW - METABOLIC SYNDROME

KW - AMINO-ACID

KW - LIVER CHOLESTEROL CONCENTRATIONS

KW - DIETARY TAURINE SUPPLEMENTATION

KW - TOTAL CYSTEINE

KW - Methionine

U2 - 10.1016/j.numecd.2011.01.008

DO - 10.1016/j.numecd.2011.01.008

M3 - Article

VL - 22

SP - 1031

EP - 1038

JO - Nutrition Metabolism And Cardiovascular Diseases

JF - Nutrition Metabolism And Cardiovascular Diseases

SN - 0939-4753

IS - 12

ER -