The association between 25-hydroxyvitamin d concentration and disability trajectories in very old adults: The newcastle 85+ study

Sarah Hakeem, Nuno Mendonca, Terry Aspray, Andrew Kingston, Carmen Ruiz-Martin, Carol Jagger, John C. Mathers, Rachel Duncan, Tom R. Hill

Research output: Contribution to journalArticle

1 Citation (Scopus)
3 Downloads (Pure)

Abstract

Background: Low vitamin D status is common in very old adults which may have adverse consequences for muscle function, a major predictor of disability. Aims: To explore the association between 25-hydroxyvitamin D [25(OH)D] concentrations and disability trajectories in very old adults and to determine whether there is an ‘adequate’ 25(OH)D concentration which might protect against a faster disability trajectory. Methodology: A total of 775 participants from the Newcastle 85+ Study for who 25(OH)D concentration at baseline was available. Serum 25(OH)D concentrations of <25 nmol/L, 25–50 nmol/L and >50 nmol/L were used as cut-offs to define low, moderate and high vitamin D status, respectively. Disability was defined as difficulty in performing 17 activities of daily living, at baseline, after 18, 36 and 60 months. Results: A three-trajectory model was derived (low-to-mild, mild-to-moderate and moderate-to-severe). In partially adjusted models, participants with 25(OH)D concentrations <25 nmol/L were more likely to have moderate and severe disability trajectories, even after adjusting for sex, living in an institution, season, cognitive status, BMI and vitamin D supplement use. However, this association disappeared after further adjustment for physical activity. Conclusions: Vitamin D status does not appear to influence the trajectories of disability in very old adults.

Original languageEnglish
Article number2742
Number of pages14
JournalNutrients
Volume12
Issue number9
DOIs
Publication statusPublished - Sep 2020

Keywords

  • Disability
  • Very old adults
  • Vitamin D status

Fingerprint Dive into the research topics of 'The association between 25-hydroxyvitamin d concentration and disability trajectories in very old adults: The newcastle 85+ study'. Together they form a unique fingerprint.

Cite this