The alternative complex III A different architecture using known building modules

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Abstract

Until recently cytochrome bc(1) complexes were the only enzymes known to be able to transfer electrons from reduced quinones to cytochrome c However a complex with the same activity and with a unique subunit composition was purified from the membranes of Rhodothermu marinus This complex named alternative complex III (ACIII) was then biochemical spectroscopic and genatically characterized Later it was observed that the presence of ACIII was not exclusive of R marinus being the genes coding for ACIII widespread at least in the Bacteria domain In this work a comprehensive description of the current knowledge on ACIII is presented The relation of ACIII with members of the complex Iron-sulfur molybdoenzyme family is investigated by analyzing all the available completely sequenced genomes It is concluded that ACIII is a new complex composed by a novel combination of modules already identified in other respiratory complexes
Original languageUnknown
Pages (from-to)1869-1876
JournalBiochimica Et Biophysica Acta-Bioenergetics
Volume1797
Issue number12
DOIs
Publication statusPublished - 1 Jan 2010

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