The Absence of HIF-1α Increases Susceptibility to Leishmania donovani Infection via Activation of BNIP3/mTOR/SREBP-1c Axis

Inês Mesquita; Carolina Ferreira; Diana Moreira; George Eduardo Gabriel Kluck; Ana Margarida Barbosa; Egídio Torrado; Ricardo Jorge Dinis-Oliveira; Luís Gafeira Gonçalves; Charles Joly Beauparlant; Arnaud Droit; Luciana Berod; Tim Sparwasser; Neelam Bodhale; Bhaskar Saha; Fernando Rodrigues; Cristina Cunha; Agostinho Carvalho; António Gil Castro; Jérôme Estaquier; Ricardo Silvestre

doi:10.1016/j.celrep.2020.02.098

The Absence of HIF-1α Increases Susceptibility to Leishmania donovani Infection via Activation of BNIP3/mTOR/SREBP-1c Axis

Inês Mesquita, Carolina Ferreira, Diana Moreira, George Eduardo Gabriel Kluck, Ana Margarida Barbosa, Egídio Torrado, Ricardo Jorge Dinis-Oliveira, Luís Gafeira Gonçalves, Charles Joly Beauparlant, Arnaud Droit, Luciana Berod, Tim Sparwasser, Neelam Bodhale, Bhaskar Saha, Fernando Rodrigues, Cristina Cunha, Agostinho Carvalho, António Gil Castro, Jérôme Estaquier, Ricardo Silvestre

Instituto de Tecnologia Química e Biológica António Xavier (ITQB)

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

Mesquita et al. show that genetic deficiency of HIF-1α in the myeloid compartment promotes de novo lipogenesis through the BNIP3/mTOR/SREBP-1c axis. This is associated with higher susceptibility to Leishmania donovani infection, which is reduced upon pharmacological inhibition of fatty acid synthesis.

Original language	English
Pages (from-to)	4052-4064.e7
Journal	Cell Reports
Volume	30
Issue number	12
DOIs	https://doi.org/10.1016/j.celrep.2020.02.098
Publication status	Published - 24 Mar 2020

Keywords

acetate
FASN
HIF-1α
lipogenesis
macrophages
myeloid cells
SREBP-1c
visceral leishmaniasis

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10.1016/j.celrep.2020.02.098Licence: CC BY

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Mesquita, I., Ferreira, C., Moreira, D., Kluck, G. E. G., Barbosa, A. M., Torrado, E., Dinis-Oliveira, R. J., Gonçalves, L. G., Beauparlant, C. J., Droit, A., Berod, L., Sparwasser, T., Bodhale, N., Saha, B., Rodrigues, F., Cunha, C., Carvalho, A., Castro, A. G., Estaquier, J., & Silvestre, R. (2020). The Absence of HIF-1α Increases Susceptibility to Leishmania donovani Infection via Activation of BNIP3/mTOR/SREBP-1c Axis. Cell Reports, 30(12), 4052-4064.e7. https://doi.org/10.1016/j.celrep.2020.02.098

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title = "The Absence of HIF-1α Increases Susceptibility to Leishmania donovani Infection via Activation of BNIP3/mTOR/SREBP-1c Axis",

abstract = "Mesquita et al. show that genetic deficiency of HIF-1α in the myeloid compartment promotes de novo lipogenesis through the BNIP3/mTOR/SREBP-1c axis. This is associated with higher susceptibility to Leishmania donovani infection, which is reduced upon pharmacological inhibition of fatty acid synthesis.",

keywords = "acetate, FASN, HIF-1α, lipogenesis, macrophages, myeloid cells, SREBP-1c, visceral leishmaniasis",

author = "In{\^e}s Mesquita and Carolina Ferreira and Diana Moreira and Kluck, \{George Eduardo Gabriel\} and Barbosa, \{Ana Margarida\} and Eg{\'i}dio Torrado and Dinis-Oliveira, \{Ricardo Jorge\} and Gon{\c c}alves, \{Lu{\'i}s Gafeira\} and Beauparlant, \{Charles Joly\} and Arnaud Droit and Luciana Berod and Tim Sparwasser and Neelam Bodhale and Bhaskar Saha and Fernando Rodrigues and Cristina Cunha and Agostinho Carvalho and Castro, \{Ant{\'o}nio Gil\} and J{\'e}r{\^o}me Estaquier and Ricardo Silvestre",

year = "2020",

month = mar,

day = "24",

doi = "10.1016/j.celrep.2020.02.098",

language = "English",

volume = "30",

pages = "4052--4064.e7",

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Mesquita, I, Ferreira, C, Moreira, D, Kluck, GEG, Barbosa, AM, Torrado, E, Dinis-Oliveira, RJ, Gonçalves, LG, Beauparlant, CJ, Droit, A, Berod, L, Sparwasser, T, Bodhale, N, Saha, B, Rodrigues, F, Cunha, C, Carvalho, A, Castro, AG, Estaquier, J & Silvestre, R 2020, 'The Absence of HIF-1α Increases Susceptibility to Leishmania donovani Infection via Activation of BNIP3/mTOR/SREBP-1c Axis', Cell Reports, vol. 30, no. 12, pp. 4052-4064.e7. https://doi.org/10.1016/j.celrep.2020.02.098

TY - JOUR

T1 - The Absence of HIF-1α Increases Susceptibility to Leishmania donovani Infection via Activation of BNIP3/mTOR/SREBP-1c Axis

AU - Mesquita, Inês

AU - Ferreira, Carolina

AU - Moreira, Diana

AU - Kluck, George Eduardo Gabriel

AU - Barbosa, Ana Margarida

AU - Torrado, Egídio

AU - Dinis-Oliveira, Ricardo Jorge

AU - Gonçalves, Luís Gafeira

AU - Beauparlant, Charles Joly

AU - Droit, Arnaud

AU - Berod, Luciana

AU - Sparwasser, Tim

AU - Bodhale, Neelam

AU - Saha, Bhaskar

AU - Rodrigues, Fernando

AU - Cunha, Cristina

AU - Carvalho, Agostinho

AU - Castro, António Gil

AU - Estaquier, Jérôme

AU - Silvestre, Ricardo

PY - 2020/3/24

Y1 - 2020/3/24

N2 - Mesquita et al. show that genetic deficiency of HIF-1α in the myeloid compartment promotes de novo lipogenesis through the BNIP3/mTOR/SREBP-1c axis. This is associated with higher susceptibility to Leishmania donovani infection, which is reduced upon pharmacological inhibition of fatty acid synthesis.

AB - Mesquita et al. show that genetic deficiency of HIF-1α in the myeloid compartment promotes de novo lipogenesis through the BNIP3/mTOR/SREBP-1c axis. This is associated with higher susceptibility to Leishmania donovani infection, which is reduced upon pharmacological inhibition of fatty acid synthesis.

KW - acetate

KW - FASN

KW - HIF-1α

KW - lipogenesis

KW - macrophages

KW - myeloid cells

KW - SREBP-1c

KW - visceral leishmaniasis

UR - https://www.scopus.com/pages/publications/85082017989

U2 - 10.1016/j.celrep.2020.02.098

DO - 10.1016/j.celrep.2020.02.098

M3 - Article

C2 - 32209468

AN - SCOPUS:85082017989

SN - 2211-1247

VL - 30

SP - 4052-4064.e7

JO - Cell Reports

JF - Cell Reports

IS - 12

ER -

The Absence of HIF-1α Increases Susceptibility to Leishmania donovani Infection via Activation of BNIP3/mTOR/SREBP-1c Axis

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