The Absence of HIF-1α Increases Susceptibility to Leishmania donovani Infection via Activation of BNIP3/mTOR/SREBP-1c Axis

Inês Mesquita, Carolina Ferreira, Diana Moreira, George Eduardo Gabriel Kluck, Ana Margarida Barbosa, Egídio Torrado, Ricardo Jorge Dinis-Oliveira, Luís Gafeira Gonçalves, Charles Joly Beauparlant, Arnaud Droit, Luciana Berod, Tim Sparwasser, Neelam Bodhale, Bhaskar Saha, Fernando Rodrigues, Cristina Cunha, Agostinho Carvalho, António Gil Castro, Jérôme Estaquier, Ricardo Silvestre

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Mesquita et al. show that genetic deficiency of HIF-1α in the myeloid compartment promotes de novo lipogenesis through the BNIP3/mTOR/SREBP-1c axis. This is associated with higher susceptibility to Leishmania donovani infection, which is reduced upon pharmacological inhibition of fatty acid synthesis.

Original languageEnglish
Pages (from-to)4052-4064.e7
JournalCell Reports
Volume30
Issue number12
DOIs
Publication statusPublished - 24 Mar 2020

Keywords

  • acetate
  • FASN
  • HIF-1α
  • lipogenesis
  • macrophages
  • myeloid cells
  • SREBP-1c
  • visceral leishmaniasis

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