Targeting malaria protein kinases

G.C. Cassiano; T.A. Tavella; M.N. Nascimento; D.A. Rodrigues; P.V.L. Cravo; C.H. Andrade; F.T.M. Costa

Targeting malaria protein kinases

G.C. Cassiano, T.A. Tavella, M.N. Nascimento, D.A. Rodrigues, P.V.L. Cravo, C.H. Andrade, F.T.M. Costa

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Malaria is one of the most impacting public health problems in tropical and subtropical areas of the globe, with approximately 200 million cases worldwide annually. In the absence of an effective vaccine, rapid treatment is vital for effective malaria control. However, parasite resistance to currently available drugs underscores the urgent need for identifying new antimalarial therapies with new mechanisms of action. Among potential drug targets for developing new antimalarial candidates, protein kinases are attractive. These enzymes catalyze the phosphorylation of several proteins, thereby regulating a variety of cellular processes and playing crucial roles in the development of all stages of the malaria parasite life cycle. Moreover, the large phylogenetic distance between Plasmodium species and its human host is reflected in marked differences in structure and function of malaria protein kinases between the homologs of both species, indicating that selectivity can be attained. In this review, we describe the functions of the different types of Plasmodium kinases and highlight the main recent advances in the discovery of kinase inhibitors as potential new antimalarial drug candidates.

Original language	English
Title of host publication	Advances in protein chemistry and structural biology
Pages	225-274
Volume	124
Publication status	Published - Jan 2021

Publication series

Name	Advances in Protein Chemistry and Structural Biology
Publisher	Elsevier
ISSN (Print)	1876-1623

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 1 No Poverty
SDG 3 Good Health and Well-being
SDG 9 Industry, Innovation, and Infrastructure
SDG 10 Reduced Inequalities
SDG 12 Responsible Consumption and Production
SDG 17 Partnerships for the Goals

Cite this

@inbook{681378963bce4704b8a3f994a9a82490,

title = "Targeting malaria protein kinases",

abstract = "Malaria is one of the most impacting public health problems in tropical and subtropical areas of the globe, with approximately 200 million cases worldwide annually. In the absence of an effective vaccine, rapid treatment is vital for effective malaria control. However, parasite resistance to currently available drugs underscores the urgent need for identifying new antimalarial therapies with new mechanisms of action. Among potential drug targets for developing new antimalarial candidates, protein kinases are attractive. These enzymes catalyze the phosphorylation of several proteins, thereby regulating a variety of cellular processes and playing crucial roles in the development of all stages of the malaria parasite life cycle. Moreover, the large phylogenetic distance between Plasmodium species and its human host is reflected in marked differences in structure and function of malaria protein kinases between the homologs of both species, indicating that selectivity can be attained. In this review, we describe the functions of the different types of Plasmodium kinases and highlight the main recent advances in the discovery of kinase inhibitors as potential new antimalarial drug candidates.",

author = "G.C. Cassiano and T.A. Tavella and M.N. Nascimento and D.A. Rodrigues and P.V.L. Cravo and C.H. Andrade and F.T.M. Costa",

note = "Funding Information: This work was supported by Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo (FAPESP, Grant 2017/18611-7), Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico (CNPq) and a joint grant of FCT of Portugal and FAPESP of Brazil, within the scope of the project ?Identification of new antimalarial treatments through a target-centered ?drug repositioning? approach? (ref PTDC/SAU-PAR/28459/2017). GCC and TAT were sponsored by a FAPESP fellowship (Grants 2015/20774-6 and 2019/27626-3, respectively). MNN was supported by a CAPES fellowship. CHA and FTMC are CNPq researcher fellows. Funding Information: This work was supported by Funda{\c c}{\~a}o de Amparo {\`a} Pesquisa do Estado de S{\~a}o Paulo (FAPESP, Grant 2017/18611-7), Conselho Nacional de Desenvolvimento Cient{\'i}fico e Tecnol{\'o}gico (CNPq) and a joint grant of FCT of Portugal and FAPESP of Brazil, within the scope of the project “Identification of new antimalarial treatments through a target-centered “drug repositioning” approach” (ref PTDC/SAU-PAR/28459/2017). GCC and TAT were sponsored by a FAPESP fellowship (Grants 2015/20774-6 and 2019/27626-3, respectively). MNN was supported by a CAPES fellowship. CHA and FTMC are CNPq researcher fellows. Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",

year = "2021",

month = jan,

language = "English",

volume = "124",

series = "Advances in Protein Chemistry and Structural Biology",

publisher = "Elsevier",

pages = "225--274",

booktitle = "Advances in protein chemistry and structural biology",

}

TY - CHAP

T1 - Targeting malaria protein kinases

AU - Cassiano, G.C.

AU - Tavella, T.A.

AU - Nascimento, M.N.

AU - Rodrigues, D.A.

AU - Cravo, P.V.L.

AU - Andrade, C.H.

AU - Costa, F.T.M.

N1 - Funding Information: This work was supported by Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo (FAPESP, Grant 2017/18611-7), Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico (CNPq) and a joint grant of FCT of Portugal and FAPESP of Brazil, within the scope of the project ?Identification of new antimalarial treatments through a target-centered ?drug repositioning? approach? (ref PTDC/SAU-PAR/28459/2017). GCC and TAT were sponsored by a FAPESP fellowship (Grants 2015/20774-6 and 2019/27626-3, respectively). MNN was supported by a CAPES fellowship. CHA and FTMC are CNPq researcher fellows. Funding Information: This work was supported by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, Grant 2017/18611-7), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and a joint grant of FCT of Portugal and FAPESP of Brazil, within the scope of the project “Identification of new antimalarial treatments through a target-centered “drug repositioning” approach” (ref PTDC/SAU-PAR/28459/2017). GCC and TAT were sponsored by a FAPESP fellowship (Grants 2015/20774-6 and 2019/27626-3, respectively). MNN was supported by a CAPES fellowship. CHA and FTMC are CNPq researcher fellows. Publisher Copyright: © 2021 Elsevier Inc.

PY - 2021/1

Y1 - 2021/1

N2 - Malaria is one of the most impacting public health problems in tropical and subtropical areas of the globe, with approximately 200 million cases worldwide annually. In the absence of an effective vaccine, rapid treatment is vital for effective malaria control. However, parasite resistance to currently available drugs underscores the urgent need for identifying new antimalarial therapies with new mechanisms of action. Among potential drug targets for developing new antimalarial candidates, protein kinases are attractive. These enzymes catalyze the phosphorylation of several proteins, thereby regulating a variety of cellular processes and playing crucial roles in the development of all stages of the malaria parasite life cycle. Moreover, the large phylogenetic distance between Plasmodium species and its human host is reflected in marked differences in structure and function of malaria protein kinases between the homologs of both species, indicating that selectivity can be attained. In this review, we describe the functions of the different types of Plasmodium kinases and highlight the main recent advances in the discovery of kinase inhibitors as potential new antimalarial drug candidates.

AB - Malaria is one of the most impacting public health problems in tropical and subtropical areas of the globe, with approximately 200 million cases worldwide annually. In the absence of an effective vaccine, rapid treatment is vital for effective malaria control. However, parasite resistance to currently available drugs underscores the urgent need for identifying new antimalarial therapies with new mechanisms of action. Among potential drug targets for developing new antimalarial candidates, protein kinases are attractive. These enzymes catalyze the phosphorylation of several proteins, thereby regulating a variety of cellular processes and playing crucial roles in the development of all stages of the malaria parasite life cycle. Moreover, the large phylogenetic distance between Plasmodium species and its human host is reflected in marked differences in structure and function of malaria protein kinases between the homologs of both species, indicating that selectivity can be attained. In this review, we describe the functions of the different types of Plasmodium kinases and highlight the main recent advances in the discovery of kinase inhibitors as potential new antimalarial drug candidates.

UR - https://www.sciencedirect.com/science/article/pii/S1876162320300821?via%3Dihub

M3 - Chapter

VL - 124

T3 - Advances in Protein Chemistry and Structural Biology

SP - 225

EP - 274

BT - Advances in protein chemistry and structural biology

ER -

Targeting malaria protein kinases

Abstract

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UN SDGs

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