The operation of cell recycle systems by membrane filtration is discussed, stressing the importance of the mutual interaction between the biological and the physical characteristics of the fermentation process. Broth circulation flow rate, dilution rate, and cell bleed rate are identified as being the most important process variables. Their effects on process performance and criteria for its adequate selection are analysed. Fermentation results for different acidogenic microorganisms are presented and the kinetic modelling of high cell density recycling systems is discussed.
|Number of pages||10|
|Journal||Chemical Engineering Science|
|Publication status||Published - 1992|