Tangential flow filtration for continuous cell recycle culture of acidogenic bacteria

J. P S G Crespo, A. M R B Xavier, M. T O Barreto, L. M D Gonçalves, J. S. Almeida, M. J T Carrondo

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The operation of cell recycle systems by membrane filtration is discussed, stressing the importance of the mutual interaction between the biological and the physical characteristics of the fermentation process. Broth circulation flow rate, dilution rate, and cell bleed rate are identified as being the most important process variables. Their effects on process performance and criteria for its adequate selection are analysed. Fermentation results for different acidogenic microorganisms are presented and the kinetic modelling of high cell density recycling systems is discussed.

Original languageEnglish
Pages (from-to)205-214
Number of pages10
JournalChemical Engineering Science
Volume47
Issue number1
DOIs
Publication statusPublished - 1992

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Continuous cell culture
Fermentation
Bacteria
Microorganisms
Dilution
Recycling
Flow rate
Membranes
Kinetics

Cite this

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Tangential flow filtration for continuous cell recycle culture of acidogenic bacteria. / Crespo, J. P S G; Xavier, A. M R B; Barreto, M. T O; Gonçalves, L. M D; Almeida, J. S.; Carrondo, M. J T.

In: Chemical Engineering Science, Vol. 47, No. 1, 1992, p. 205-214.

Research output: Contribution to journalArticle

TY - JOUR

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AU - Crespo, J. P S G

AU - Xavier, A. M R B

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AU - Almeida, J. S.

AU - Carrondo, M. J T

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