Tangential flow filtration for continuous cell recycle culture of acidogenic bacteria

J. P S G Crespo, A. M R B Xavier, M. T O Barreto, L. M D Gonçalves, J. S. Almeida, M. J T Carrondo

Research output: Contribution to journalArticle

19 Citations (Scopus)


The operation of cell recycle systems by membrane filtration is discussed, stressing the importance of the mutual interaction between the biological and the physical characteristics of the fermentation process. Broth circulation flow rate, dilution rate, and cell bleed rate are identified as being the most important process variables. Their effects on process performance and criteria for its adequate selection are analysed. Fermentation results for different acidogenic microorganisms are presented and the kinetic modelling of high cell density recycling systems is discussed.

Original languageEnglish
Pages (from-to)205-214
Number of pages10
JournalChemical Engineering Science
Issue number1
Publication statusPublished - 1992


Cite this