Tangential flow filtration for continuous cell recycle culture of acidogenic bacteria

J. P S G Crespo; A. M R B Xavier; M. T O Barreto; L. M D Gonçalves; J. S. Almeida; M. J T Carrondo

doi:10.1016/0009-2509(92)80214-W

Tangential flow filtration for continuous cell recycle culture of acidogenic bacteria

J. P S G Crespo, A. M R B Xavier, M. T O Barreto, L. M D Gonçalves, J. S. Almeida, M. J T Carrondo

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

The operation of cell recycle systems by membrane filtration is discussed, stressing the importance of the mutual interaction between the biological and the physical characteristics of the fermentation process. Broth circulation flow rate, dilution rate, and cell bleed rate are identified as being the most important process variables. Their effects on process performance and criteria for its adequate selection are analysed. Fermentation results for different acidogenic microorganisms are presented and the kinetic modelling of high cell density recycling systems is discussed.

Original language	English
Pages (from-to)	205-214
Number of pages	10
Journal	Chemical Engineering Science
Volume	47
Issue number	1
DOIs	https://doi.org/10.1016/0009-2509(92)80214-W
Publication status	Published - 1992

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abstract = "The operation of cell recycle systems by membrane filtration is discussed, stressing the importance of the mutual interaction between the biological and the physical characteristics of the fermentation process. Broth circulation flow rate, dilution rate, and cell bleed rate are identified as being the most important process variables. Their effects on process performance and criteria for its adequate selection are analysed. Fermentation results for different acidogenic microorganisms are presented and the kinetic modelling of high cell density recycling systems is discussed.",

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AU - Crespo, J. P S G

AU - Xavier, A. M R B

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AU - Gonçalves, L. M D

AU - Almeida, J. S.

AU - Carrondo, M. J T

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AB - The operation of cell recycle systems by membrane filtration is discussed, stressing the importance of the mutual interaction between the biological and the physical characteristics of the fermentation process. Broth circulation flow rate, dilution rate, and cell bleed rate are identified as being the most important process variables. Their effects on process performance and criteria for its adequate selection are analysed. Fermentation results for different acidogenic microorganisms are presented and the kinetic modelling of high cell density recycling systems is discussed.

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DO - 10.1016/0009-2509(92)80214-W

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JF - Chemical Engineering Science

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ER -

Tangential flow filtration for continuous cell recycle culture of acidogenic bacteria

Abstract

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