T lymphocytes alterations are associated with oxidized LDL, troponin T, white blood cells and C-reactive protein during acute myocardial infarction

Patrícia Napoleão, Mafalda Selas, Cláudia Freixo, Miguel Mota Carmo, Ana Maria Viegas-Crespo, Rui Cruz Ferreira, Teresa Pinheiro

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Auto-immune responses are associated with oxidized LDL (ox-LDL) release, a key factor in plaque destabilization. Data on the relationship between ox-LDL and T lymphocytes in human populations remains scarce. T cells also react with other molecules from the lesion and/or damage the myocardium. OBJECTIVE: The objective of the present study was to examine the relationship between circulating T lymphocytes, ox-LDL, markers of myocardial necrosis (cTnT), myocardial dysfunction (N-terminal pro-brain natriuretic peptide-NT-proBNP) and inflammation (C-reactive protein-CRP) in the setting of acute myocardial infarction. METHODS: A longitudinal study of 55 patients with ST-elevation myocardial infarction (STEMI) were evaluated at three time points: admission, 2 and 40 days following admission, together with 30 patients with stable angina (SA) and 56 subjects without coronary artery disease serving as controls (CTR). RESULTS: STEMI patients had maximal ox-LDL values and minimal levels of CD3+ T lymphocytes at admission, which was normalized during the recovery period. The increasing trend of CD3+ T cells was positively associated with an ox-LDL decline over time. CRP and cTnT longitudinal variations were negatively associated with the CD3+ T-cell increasing trend. These associations were not found in SA patients or controls. CONCLUSIONS: The associations found between CD3+ T lymphocytes, ox-LDL and cTnT suggest a specificity of the immune response in AMI towards arterial and myocardial inflammation and remodelling.

Original languageEnglish
Pages (from-to)57-66
Number of pages10
JournalClinical Hemorheology and Microcirculation
Volume56
Issue number1
DOIs
Publication statusPublished - 2014

Fingerprint

Troponin T
C-Reactive Protein
Leukocytes
Myocardial Infarction
T-Lymphocytes
Stable Angina
Arteritis
Brain Natriuretic Peptide
oxidized low density lipoprotein
Longitudinal Studies
Coronary Artery Disease
Myocardium
Necrosis
Inflammation
Population

Keywords

  • Acute coronary syndromes
  • C-reactive protein
  • Cardiac troponin T
  • Longitudinal study
  • Oxidized LDL
  • T lymphocytes

Cite this

Napoleão, Patrícia ; Selas, Mafalda ; Freixo, Cláudia ; Carmo, Miguel Mota ; Viegas-Crespo, Ana Maria ; Ferreira, Rui Cruz ; Pinheiro, Teresa. / T lymphocytes alterations are associated with oxidized LDL, troponin T, white blood cells and C-reactive protein during acute myocardial infarction. In: Clinical Hemorheology and Microcirculation. 2014 ; Vol. 56, No. 1. pp. 57-66.
@article{0b7d35caa1004d04959f2eca11919518,
title = "T lymphocytes alterations are associated with oxidized LDL, troponin T, white blood cells and C-reactive protein during acute myocardial infarction",
abstract = "BACKGROUND: Auto-immune responses are associated with oxidized LDL (ox-LDL) release, a key factor in plaque destabilization. Data on the relationship between ox-LDL and T lymphocytes in human populations remains scarce. T cells also react with other molecules from the lesion and/or damage the myocardium. OBJECTIVE: The objective of the present study was to examine the relationship between circulating T lymphocytes, ox-LDL, markers of myocardial necrosis (cTnT), myocardial dysfunction (N-terminal pro-brain natriuretic peptide-NT-proBNP) and inflammation (C-reactive protein-CRP) in the setting of acute myocardial infarction. METHODS: A longitudinal study of 55 patients with ST-elevation myocardial infarction (STEMI) were evaluated at three time points: admission, 2 and 40 days following admission, together with 30 patients with stable angina (SA) and 56 subjects without coronary artery disease serving as controls (CTR). RESULTS: STEMI patients had maximal ox-LDL values and minimal levels of CD3+ T lymphocytes at admission, which was normalized during the recovery period. The increasing trend of CD3+ T cells was positively associated with an ox-LDL decline over time. CRP and cTnT longitudinal variations were negatively associated with the CD3+ T-cell increasing trend. These associations were not found in SA patients or controls. CONCLUSIONS: The associations found between CD3+ T lymphocytes, ox-LDL and cTnT suggest a specificity of the immune response in AMI towards arterial and myocardial inflammation and remodelling.",
keywords = "Acute coronary syndromes, C-reactive protein, Cardiac troponin T, Longitudinal study, Oxidized LDL, T lymphocytes",
author = "Patr{\'i}cia Napole{\~a}o and Mafalda Selas and Cl{\'a}udia Freixo and Carmo, {Miguel Mota} and Viegas-Crespo, {Ana Maria} and Ferreira, {Rui Cruz} and Teresa Pinheiro",
note = "PMID:23271203 WOS:000332245300006",
year = "2014",
doi = "10.3233/CH-121665",
language = "English",
volume = "56",
pages = "57--66",
journal = "Clinical Hemorheology and Microcirculation",
issn = "1386-0291",
publisher = "IOS Press; 1999",
number = "1",

}

T lymphocytes alterations are associated with oxidized LDL, troponin T, white blood cells and C-reactive protein during acute myocardial infarction. / Napoleão, Patrícia; Selas, Mafalda; Freixo, Cláudia; Carmo, Miguel Mota; Viegas-Crespo, Ana Maria; Ferreira, Rui Cruz; Pinheiro, Teresa.

In: Clinical Hemorheology and Microcirculation, Vol. 56, No. 1, 2014, p. 57-66.

Research output: Contribution to journalArticle

TY - JOUR

T1 - T lymphocytes alterations are associated with oxidized LDL, troponin T, white blood cells and C-reactive protein during acute myocardial infarction

AU - Napoleão, Patrícia

AU - Selas, Mafalda

AU - Freixo, Cláudia

AU - Carmo, Miguel Mota

AU - Viegas-Crespo, Ana Maria

AU - Ferreira, Rui Cruz

AU - Pinheiro, Teresa

N1 - PMID:23271203 WOS:000332245300006

PY - 2014

Y1 - 2014

N2 - BACKGROUND: Auto-immune responses are associated with oxidized LDL (ox-LDL) release, a key factor in plaque destabilization. Data on the relationship between ox-LDL and T lymphocytes in human populations remains scarce. T cells also react with other molecules from the lesion and/or damage the myocardium. OBJECTIVE: The objective of the present study was to examine the relationship between circulating T lymphocytes, ox-LDL, markers of myocardial necrosis (cTnT), myocardial dysfunction (N-terminal pro-brain natriuretic peptide-NT-proBNP) and inflammation (C-reactive protein-CRP) in the setting of acute myocardial infarction. METHODS: A longitudinal study of 55 patients with ST-elevation myocardial infarction (STEMI) were evaluated at three time points: admission, 2 and 40 days following admission, together with 30 patients with stable angina (SA) and 56 subjects without coronary artery disease serving as controls (CTR). RESULTS: STEMI patients had maximal ox-LDL values and minimal levels of CD3+ T lymphocytes at admission, which was normalized during the recovery period. The increasing trend of CD3+ T cells was positively associated with an ox-LDL decline over time. CRP and cTnT longitudinal variations were negatively associated with the CD3+ T-cell increasing trend. These associations were not found in SA patients or controls. CONCLUSIONS: The associations found between CD3+ T lymphocytes, ox-LDL and cTnT suggest a specificity of the immune response in AMI towards arterial and myocardial inflammation and remodelling.

AB - BACKGROUND: Auto-immune responses are associated with oxidized LDL (ox-LDL) release, a key factor in plaque destabilization. Data on the relationship between ox-LDL and T lymphocytes in human populations remains scarce. T cells also react with other molecules from the lesion and/or damage the myocardium. OBJECTIVE: The objective of the present study was to examine the relationship between circulating T lymphocytes, ox-LDL, markers of myocardial necrosis (cTnT), myocardial dysfunction (N-terminal pro-brain natriuretic peptide-NT-proBNP) and inflammation (C-reactive protein-CRP) in the setting of acute myocardial infarction. METHODS: A longitudinal study of 55 patients with ST-elevation myocardial infarction (STEMI) were evaluated at three time points: admission, 2 and 40 days following admission, together with 30 patients with stable angina (SA) and 56 subjects without coronary artery disease serving as controls (CTR). RESULTS: STEMI patients had maximal ox-LDL values and minimal levels of CD3+ T lymphocytes at admission, which was normalized during the recovery period. The increasing trend of CD3+ T cells was positively associated with an ox-LDL decline over time. CRP and cTnT longitudinal variations were negatively associated with the CD3+ T-cell increasing trend. These associations were not found in SA patients or controls. CONCLUSIONS: The associations found between CD3+ T lymphocytes, ox-LDL and cTnT suggest a specificity of the immune response in AMI towards arterial and myocardial inflammation and remodelling.

KW - Acute coronary syndromes

KW - C-reactive protein

KW - Cardiac troponin T

KW - Longitudinal study

KW - Oxidized LDL

KW - T lymphocytes

UR - http://www.scopus.com/inward/record.url?scp=84895805846&partnerID=8YFLogxK

U2 - 10.3233/CH-121665

DO - 10.3233/CH-121665

M3 - Article

VL - 56

SP - 57

EP - 66

JO - Clinical Hemorheology and Microcirculation

JF - Clinical Hemorheology and Microcirculation

SN - 1386-0291

IS - 1

ER -