Lúpus eritematoso sistiémico e anemia.

Translated title of the contribution: Systemic lupus erythematosus and anaemia

S. Falcão, R. C. Barros, M Mateus, P. Nero, A. P Alves De Matos, José Bravo Pimentão, I. Ribeiro, André Weigert, Jaime Branco

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Abstract

The authors report the case of a 48-years-old Caucasian women, with a previous diagnosis of systemic lupus erythematosus characterized by asthenia, fever, skin rash, alopecia, Raynaud's phenomenon, arthritis, pericardial effusion, interstitial pulmonary involvement, diffuse proliferative glomerulonephritis with crescents and anemia. The presence of severe anemia refractory to high doses of glucocorticoids (1 mg/ /Kg/day), iron therapy and blood transfusions, associated with a low reticulocyte count determined the execution of a bone marrow aspiration, biopsy and immunophenotyping, which were compatible with the diagnosis of Myelodysplastic Syndrome. The treatment with erythropoietin (5.000U 3x/week) and cyclophosphamide pulses (1 gr/m(2) month) induced complete regression of morphologic bone marrow changes and anemia. The main causes of anemia in lupus patients are discussed.

Original languagePortuguese
Pages (from-to)73-79
Number of pages7
JournalActa reumatologica portuguesa
Volume32
Issue number1
Publication statusPublished - Jan 2007

Keywords

  • systemic lupus erythematosus
  • myelodysplastic syndrome
  • anemia

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    Falcão, S., Barros, R. C., Mateus, M., Nero, P., De Matos, A. P. A., Pimentão, J. B., ... Branco, J. (2007). Lúpus eritematoso sistiémico e anemia. Acta reumatologica portuguesa, 32(1), 73-79.