Systematic review on recent potential biomarkers of chronic obstructive pulmonary disease

Eda Aydindogan, Deborah Penque, Jerome Zoidakis

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death worldwide and associated with decreased lung function and inflammation. The heterogeneity of COPD and its molecular and clinical features hinder efficient patient stratification and introduction of personalized therapeutic approaches. The available clinical tools do not efficiently predict the progression and exacerbations of the disease. Areas covered: An overview of the most recent studies on putative COPD protein biomarkers and the challenges for implementing their use in the clinical setting is presented. Expert commentary: Proteomics biomarker discovery in COPD has mostly focused on approaches evaluating specific proteins on a limited number of samples. The most promising protein candidates can be classified into five main biological categories: extracellular matrix (ECM) remodeling, inflammation/immune response, oxidative stress response, vascular tone regulation, and lipid metabolism. To efficiently stratify COPD patients and predict exacerbations, it will be necessary to implement biomarker panels to better represent the complex pathophysiology of this disease. The application of unbiased proteomics and bioinformatics followed by appropriate clinical validation studies will contribute to the achievement of this aim while increasing the number of validated biomarkers that can enter the qualification processes by the regulatory entities.

Original languageEnglish
Pages (from-to)37-45
Number of pages9
JournalExpert Review Of Molecular Diagnostics
Volume19
Issue number1
Early online date18 Dec 2018
DOIs
Publication statusPublished - 2 Jan 2019

Keywords

  • biomarkers
  • COPD
  • exacerbations
  • mortality
  • Protein biomarkers
  • proteomics

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