Synthesis, spectroscopic studies and in vitro antibacterial activity of Ibuprofen and its derived metal complexes

Cristina Nunez; Adrián Fernández -Lodeiro; Javier Fernández-Lodeiro; Julia Carballo; José Luis Capelo; Carlos Lodeiro

doi:10.1016/j.inoche.2014.03.039

Synthesis, spectroscopic studies and in vitro antibacterial activity of Ibuprofen and its derived metal complexes

Cristina Nunez, Adrián Fernández -Lodeiro, Javier Fernández-Lodeiro, Julia Carballo, José Luis Capelo, Carlos Lodeiro

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Complexes of Na+, Ag+, Ca2+, Mg2+, Cu2+, Zn2+ and Hg2+ metal ions with the anti-inflammatory drugα-methyl-4-(2-methylpropyl)benzene acetic acid (Ibuprofen) have been synthesized and fully characterized.The IR spectroscopy data showed that Ibuprofen interacts with metal ions through the deprotonated carboxylategroup in the bidentate form.Ibuprofen and its Ag+ and Hg2+ complexes showed antibacterial activity against the Gram-positive bacteria(Staphylococcus aureus and Listeria monocytogenes). The metal complexes resulted significantly more effectivethan the free Ibuprofen drug.

Original language	English
Pages (from-to)	61-65
Number of pages	5
Journal	Inorganic Chemistry Communications
Volume	45
DOIs	https://doi.org/10.1016/j.inoche.2014.03.039 https://doi.org/10.1016/j.inoche.2014.03.039
Publication status	Published - Jul 2014

Keywords

Ibuprofen
Synthesis
Antibacterial
Mercury(II)
Silver(I)

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@article{aeee94f0600e41e8ac6c28845e85bf2b,

title = "Synthesis, spectroscopic studies and in vitro antibacterial activity of Ibuprofen and its derived metal complexes",

abstract = "Complexes of Na+, Ag+, Ca2+, Mg2+, Cu2+, Zn2+ and Hg2+ metal ions with the anti-inflammatory drugα-methyl-4-(2-methylpropyl)benzene acetic acid (Ibuprofen) have been synthesized and fully characterized.The IR spectroscopy data showed that Ibuprofen interacts with metal ions through the deprotonated carboxylategroup in the bidentate form.Ibuprofen and its Ag+ and Hg2+ complexes showed antibacterial activity against the Gram-positive bacteria(Staphylococcus aureus and Listeria monocytogenes). The metal complexes resulted significantly more effectivethan the free Ibuprofen drug.",

keywords = "Ibuprofen, Synthesis, Antibacterial, Mercury(II), Silver(I)",

author = "Cristina Nunez and {Fern{\'a}ndez -Lodeiro}, Adri{\'a}n and Javier Fern{\'a}ndez-Lodeiro and Julia Carballo and Capelo, {Jos{\'e} Luis} and Carlos Lodeiro",

note = "Funding Information: C.N. thanks the Xunta de Galicia (Spain) for her postdoctoral contract (I2C program); J. Fern{\'a}ndez-Lodeiro acknowledges FAPESP (Fundo de Apoio a Pesquisa do Estado de Sao Paulo, Brazil) for a postdoctoral Grant. PROTEOMASS Scientific Society (Portugal) and PROTEOMASS Scientific Society (Spain) are also acknowledged for funding. A. Fern{\'a}ndez-Lodeiro acknowledges PROTEOMASS Scientific Society (Portugal) for financial support. Authors also thank to REQUIMTE-FCT PEst-C/EQB/LA0006/2013.",

year = "2014",

month = jul,

doi = "10.1016/j.inoche.2014.03.039",

language = "English",

volume = "45",

pages = "61--65",

journal = "Inorganic Chemistry Communications",

issn = "1387-7003",

publisher = "Elsevier",

}

TY - JOUR

T1 - Synthesis, spectroscopic studies and in vitro antibacterial activity of Ibuprofen and its derived metal complexes

AU - Nunez, Cristina

AU - Fernández -Lodeiro, Adrián

AU - Fernández-Lodeiro, Javier

AU - Carballo, Julia

AU - Capelo, José Luis

AU - Lodeiro, Carlos

N1 - Funding Information: C.N. thanks the Xunta de Galicia (Spain) for her postdoctoral contract (I2C program); J. Fernández-Lodeiro acknowledges FAPESP (Fundo de Apoio a Pesquisa do Estado de Sao Paulo, Brazil) for a postdoctoral Grant. PROTEOMASS Scientific Society (Portugal) and PROTEOMASS Scientific Society (Spain) are also acknowledged for funding. A. Fernández-Lodeiro acknowledges PROTEOMASS Scientific Society (Portugal) for financial support. Authors also thank to REQUIMTE-FCT PEst-C/EQB/LA0006/2013.

PY - 2014/7

Y1 - 2014/7

N2 - Complexes of Na+, Ag+, Ca2+, Mg2+, Cu2+, Zn2+ and Hg2+ metal ions with the anti-inflammatory drugα-methyl-4-(2-methylpropyl)benzene acetic acid (Ibuprofen) have been synthesized and fully characterized.The IR spectroscopy data showed that Ibuprofen interacts with metal ions through the deprotonated carboxylategroup in the bidentate form.Ibuprofen and its Ag+ and Hg2+ complexes showed antibacterial activity against the Gram-positive bacteria(Staphylococcus aureus and Listeria monocytogenes). The metal complexes resulted significantly more effectivethan the free Ibuprofen drug.

AB - Complexes of Na+, Ag+, Ca2+, Mg2+, Cu2+, Zn2+ and Hg2+ metal ions with the anti-inflammatory drugα-methyl-4-(2-methylpropyl)benzene acetic acid (Ibuprofen) have been synthesized and fully characterized.The IR spectroscopy data showed that Ibuprofen interacts with metal ions through the deprotonated carboxylategroup in the bidentate form.Ibuprofen and its Ag+ and Hg2+ complexes showed antibacterial activity against the Gram-positive bacteria(Staphylococcus aureus and Listeria monocytogenes). The metal complexes resulted significantly more effectivethan the free Ibuprofen drug.

KW - Ibuprofen

KW - Synthesis

KW - Antibacterial

KW - Mercury(II)

KW - Silver(I)

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U2 - 10.1016/j.inoche.2014.03.039

DO - 10.1016/j.inoche.2014.03.039

M3 - Article

SN - 1387-7003

VL - 45

SP - 61

EP - 65

JO - Inorganic Chemistry Communications

JF - Inorganic Chemistry Communications

ER -

Synthesis, spectroscopic studies and in vitro antibacterial activity of Ibuprofen and its derived metal complexes

Abstract

Keywords

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