TY - JOUR
T1 - Synthesis, spectroscopic studies and in vitro antibacterial activity of Ibuprofen and its derived metal complexes
AU - Nunez, Cristina
AU - Fernández -Lodeiro, Adrián
AU - Fernández-Lodeiro, Javier
AU - Carballo, Julia
AU - Capelo, José Luis
AU - Lodeiro, Carlos
N1 - Funding Information:
C.N. thanks the Xunta de Galicia (Spain) for her postdoctoral contract (I2C program); J. Fernández-Lodeiro acknowledges FAPESP (Fundo de Apoio a Pesquisa do Estado de Sao Paulo, Brazil) for a postdoctoral Grant. PROTEOMASS Scientific Society (Portugal) and PROTEOMASS Scientific Society (Spain) are also acknowledged for funding. A. Fernández-Lodeiro acknowledges PROTEOMASS Scientific Society (Portugal) for financial support. Authors also thank to REQUIMTE-FCT PEst-C/EQB/LA0006/2013.
PY - 2014/7
Y1 - 2014/7
N2 - Complexes of Na+, Ag+, Ca2+, Mg2+, Cu2+, Zn2+ and Hg2+ metal ions with the anti-inflammatory drugα-methyl-4-(2-methylpropyl)benzene acetic acid (Ibuprofen) have been synthesized and fully characterized.The IR spectroscopy data showed that Ibuprofen interacts with metal ions through the deprotonated carboxylategroup in the bidentate form.Ibuprofen and its Ag+ and Hg2+ complexes showed antibacterial activity against the Gram-positive bacteria(Staphylococcus aureus and Listeria monocytogenes). The metal complexes resulted significantly more effectivethan the free Ibuprofen drug.
AB - Complexes of Na+, Ag+, Ca2+, Mg2+, Cu2+, Zn2+ and Hg2+ metal ions with the anti-inflammatory drugα-methyl-4-(2-methylpropyl)benzene acetic acid (Ibuprofen) have been synthesized and fully characterized.The IR spectroscopy data showed that Ibuprofen interacts with metal ions through the deprotonated carboxylategroup in the bidentate form.Ibuprofen and its Ag+ and Hg2+ complexes showed antibacterial activity against the Gram-positive bacteria(Staphylococcus aureus and Listeria monocytogenes). The metal complexes resulted significantly more effectivethan the free Ibuprofen drug.
KW - Ibuprofen
KW - Synthesis
KW - Antibacterial
KW - Mercury(II)
KW - Silver(I)
UR - http://www.scopus.com/inward/record.url?scp=84899863322&partnerID=8YFLogxK
U2 - 10.1016/j.inoche.2014.03.039
DO - 10.1016/j.inoche.2014.03.039
M3 - Article
SN - 1387-7003
VL - 45
SP - 61
EP - 65
JO - Inorganic Chemistry Communications
JF - Inorganic Chemistry Communications
ER -