Synthesis, spectroscopic studies and in vitro antibacterial activity of Ibuprofen and its derived metal complexes

Cristina Nunez, Adrian Fernandez-Lodeiro, Javier Fernández-Lodeiro, Julia Carballo, José Luis Capelo, Carlos Lodeiro

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Complexes of Na+, Ag+, Ca2+, Mg2+, Cu2+, Zn2+ and Hg2+ metal ions with the anti-inflammatory drugα-methyl-4-(2-methylpropyl)benzene acetic acid (Ibuprofen) have been synthesized and fully characterized.The IR spectroscopy data showed that Ibuprofen interacts with metal ions through the deprotonated carboxylategroup in the bidentate form.Ibuprofen and its Ag+ and Hg2+ complexes showed antibacterial activity against the Gram-positive bacteria(Staphylococcus aureus and Listeria monocytogenes). The metal complexes resulted significantly more effectivethan the free Ibuprofen drug.
Original languageEnglish
Pages (from-to)61-65
Number of pages5
JournalInorganic Chemistry Communications
Volume45
DOIs
Publication statusPublished - Jul 2014

Keywords

  • Ibuprofen
  • Synthesis
  • Antibacterial
  • Mercury(II)
  • Silver(I)

Fingerprint Dive into the research topics of 'Synthesis, spectroscopic studies and in vitro antibacterial activity of Ibuprofen and its derived metal complexes'. Together they form a unique fingerprint.

Cite this