Synthesis of mesoporous silica coated gold nanorods loaded with methylene blue and its potentials in antibacterial applications

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Abstract

In this work, the successful preparation and characterization of gold nanorods (AuNRs) coated with a mesoporous silica shell (AuNRs@Simes) was achieved. Conjugation with methylene blue (MB) as a model drug using ultrasound-stimulated loading has been explored for further application in light-mediated antibacterial studies. Lyophilization of this conjugated nanosystem was analyzed using trehalose (TRH) as a cryogenic protector. The obtained stable dry formulation shows potent antimicrobial activity against Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria after a simple post-treatment irradiation method with a red laser during a short time period.

Original languageEnglish
Article number1338
JournalNanomaterials
Volume11
Issue number5
DOIs
Publication statusPublished - 19 May 2021

Keywords

  • Antibacterial activity
  • Gold nanoparticles
  • Gold nanorod
  • Mesoporous silica
  • Methylene blue

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