Synthesis of Bis(3-indolyl)methanes Mediated by Potassium tert-Butoxide

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The indole moiety is an important N-heterocycle found in natural products, and a key structural component of many value-added chemicals including pharmaceuticals. In particular, bis(3-indolyl)methanes (BIMs) are an important subgroup of indoles, composed of two indole units. Herein, we report the development of a simple method to access BIMs derivatives in yields of up to 77 % by exploiting a tBuOK-mediated coupling reaction of indoles and benzyl alcohols.
Original languageEnglish
Article numbere202200265
Number of pages7
Issue number1
Publication statusPublished - Jan 2023


  • bis(indolyl)methanes
  • indole
  • tBuOK
  • radicals
  • benzylalcohols


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