Synthesis of Bis(3-indolyl)methanes Mediated by Potassium tert-Butoxide

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)
13 Downloads (Pure)

Abstract

The indole moiety is an important N-heterocycle found in natural products, and a key structural component of many value-added chemicals including pharmaceuticals. In particular, bis(3-indolyl)methanes (BIMs) are an important subgroup of indoles, composed of two indole units. Herein, we report the development of a simple method to access BIMs derivatives in yields of up to 77 % by exploiting a tBuOK-mediated coupling reaction of indoles and benzyl alcohols.
Original languageEnglish
Article numbere202200265
Number of pages7
JournalChemistryOpen
Volume12
Issue number1
DOIs
Publication statusPublished - Jan 2023

Keywords

  • bis(indolyl)methanes
  • indole
  • tBuOK
  • radicals
  • benzylalcohols

Fingerprint

Dive into the research topics of 'Synthesis of Bis(3-indolyl)methanes Mediated by Potassium tert-Butoxide'. Together they form a unique fingerprint.

Cite this