Synthesis, morphostructure, surface chemistry and preclinical studies of nanoporous rice husk-derived biochars for gastrointestinal detoxification

J. M. Jandosov, L. I. Mikhalovska, C. A. Howell, D. I. Chenchik, B. K. Kosher, S. B. Lyubchik, J. Silvestre-Albero, N. T. Ablaikhanova, G. T. Srailova, S. T. Tuleukhanov, S. V. Mikhalovsky

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

This article summarizes the methodology of synthesis, surface functionalization and structural properties of rice husk-derived nanostructured carbon enterosorbents (biochars) in connection with the preliminary in vitro study results of uraemic toxin adsorption in model experiments, as well as preclinical trials in vivo. The obtained nanostructured carbon sorbents were studied using a number of modern physicochemical methods of investigation: low-temperature nitrogen adsorption, isotherms recording and calculation of the specific surface area, pore volumes were carried out using the Autosorb-1 "Quantachrome" device. Scanning electron microscopy and EDS-analysis. Mercury intrusion porosimetry analysis of the ACs were accomplished using "Quantachrome Poremaster" data analysis software. In vitro adsorption results assessed by use of HPLC and UV-spectroscopy for the nanostructured carbon sorbents with respect to the investigated low-molecule toxins suggest that the rice husks-derived carbon enterosorbents modified with the functional groups are able to reduce clinically significant levels of uraemic toxins and are comparable to the commercial enterosorbents. Based on the results of the comparative analysis for biocompatibility of canine kidney epithelial cells it was determined that the samples of the modified sorbents CRH-P-450 and CRH-475-KOH-850-N do not exhibit cytotoxicity in comparison with the commercial carbon enterosorbent «Adsorbix Extra». According to the results of the in vivo studies, it was determined that there was a positive effect of the enterosorbent CRH-P-450 on uremia and intoxication.

Original languageEnglish
Pages (from-to)303-313
Number of pages11
JournalEurasian Chemico-Technological Journal
Volume19
Issue number4
DOIs
Publication statusPublished - 2017

Fingerprint

Detoxification
rice
Surface chemistry
Carbon
chemistry
sorbents
Sorbents
carbon
synthesis
adsorption
intoxication
Adsorption
kidneys
biocompatibility
Cytotoxicity
Ultraviolet spectroscopy
Mercury
Biocompatibility
Adsorption isotherms
intrusion

Keywords

  • HIGH-ASH BIOMASS
  • ACTIVATION
  • CARBON

Cite this

Jandosov, J. M. ; Mikhalovska, L. I. ; Howell, C. A. ; Chenchik, D. I. ; Kosher, B. K. ; Lyubchik, S. B. ; Silvestre-Albero, J. ; Ablaikhanova, N. T. ; Srailova, G. T. ; Tuleukhanov, S. T. ; Mikhalovsky, S. V. / Synthesis, morphostructure, surface chemistry and preclinical studies of nanoporous rice husk-derived biochars for gastrointestinal detoxification. In: Eurasian Chemico-Technological Journal. 2017 ; Vol. 19, No. 4. pp. 303-313.
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Jandosov, JM, Mikhalovska, LI, Howell, CA, Chenchik, DI, Kosher, BK, Lyubchik, SB, Silvestre-Albero, J, Ablaikhanova, NT, Srailova, GT, Tuleukhanov, ST & Mikhalovsky, SV 2017, 'Synthesis, morphostructure, surface chemistry and preclinical studies of nanoporous rice husk-derived biochars for gastrointestinal detoxification', Eurasian Chemico-Technological Journal, vol. 19, no. 4, pp. 303-313. https://doi.org/10.18321/ectj678

Synthesis, morphostructure, surface chemistry and preclinical studies of nanoporous rice husk-derived biochars for gastrointestinal detoxification. / Jandosov, J. M.; Mikhalovska, L. I.; Howell, C. A.; Chenchik, D. I.; Kosher, B. K.; Lyubchik, S. B.; Silvestre-Albero, J.; Ablaikhanova, N. T.; Srailova, G. T.; Tuleukhanov, S. T.; Mikhalovsky, S. V.

In: Eurasian Chemico-Technological Journal, Vol. 19, No. 4, 2017, p. 303-313.

Research output: Contribution to journalArticle

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T1 - Synthesis, morphostructure, surface chemistry and preclinical studies of nanoporous rice husk-derived biochars for gastrointestinal detoxification

AU - Jandosov, J. M.

AU - Mikhalovska, L. I.

AU - Howell, C. A.

AU - Chenchik, D. I.

AU - Kosher, B. K.

AU - Lyubchik, S. B.

AU - Silvestre-Albero, J.

AU - Ablaikhanova, N. T.

AU - Srailova, G. T.

AU - Tuleukhanov, S. T.

AU - Mikhalovsky, S. V.

N1 - Sem PDF. Royal Academy of Engineering within the Industry Academia Partnership Programme (IAPP\1516\3) EU "Horizon" programme under the umbrella of "Marie Sklodowska-Curie Research and Innovation Staff Exchange" (H-MSCA-RISE) (734641/Acronym: NanoMed)

PY - 2017

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N2 - This article summarizes the methodology of synthesis, surface functionalization and structural properties of rice husk-derived nanostructured carbon enterosorbents (biochars) in connection with the preliminary in vitro study results of uraemic toxin adsorption in model experiments, as well as preclinical trials in vivo. The obtained nanostructured carbon sorbents were studied using a number of modern physicochemical methods of investigation: low-temperature nitrogen adsorption, isotherms recording and calculation of the specific surface area, pore volumes were carried out using the Autosorb-1 "Quantachrome" device. Scanning electron microscopy and EDS-analysis. Mercury intrusion porosimetry analysis of the ACs were accomplished using "Quantachrome Poremaster" data analysis software. In vitro adsorption results assessed by use of HPLC and UV-spectroscopy for the nanostructured carbon sorbents with respect to the investigated low-molecule toxins suggest that the rice husks-derived carbon enterosorbents modified with the functional groups are able to reduce clinically significant levels of uraemic toxins and are comparable to the commercial enterosorbents. Based on the results of the comparative analysis for biocompatibility of canine kidney epithelial cells it was determined that the samples of the modified sorbents CRH-P-450 and CRH-475-KOH-850-N do not exhibit cytotoxicity in comparison with the commercial carbon enterosorbent «Adsorbix Extra». According to the results of the in vivo studies, it was determined that there was a positive effect of the enterosorbent CRH-P-450 on uremia and intoxication.

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