Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 22-29 |
| Number of pages | 8 |
| Journal | Journal Of Medicinal Chemistry |
| Volume | 12 |
| Issue number | 1 |
| Early online date | 2016 |
| DOIs | |
| Publication status | Published - 2016 |
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Keywords
- Biological activity
- sucrose derivatization
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Synthesis, Characterization, Antimicrobial and Antitumor Activities of Sucrose Octa(N-ethyl)carbamate. / Barros, Maria Teresa; Petrova, Krasimira Todorova Markova; Raposo, Cláudia D.; Calheta, R.C.; Sokovi, Marina ; Ferreira , Isabel C. F. .
In: Journal Of Medicinal Chemistry, Vol. 12, No. 1, 2016, p. 22-29.Research output: Contribution to journal › Article
TY - JOUR
T1 - Synthesis, Characterization, Antimicrobial and Antitumor Activities of Sucrose Octa(N-ethyl)carbamate
AU - Barros, Maria Teresa
AU - Petrova, Krasimira Todorova Markova
AU - Raposo, Cláudia D.
AU - Calheta, R.C.
AU - Sokovi, Marina
AU - Ferreira , Isabel C. F.
N1 - info:eu-repo/grantAgreement/FCT/3599-PPCDT/132893/PT# info:eu-repo/grantAgreement/FCT/3599-PPCDT/127013/PT# Fundacao para a Ciencia e a Tecnologia PEst-OE/AGR/UI0690/2011; Serbian Ministry of Education and Science (173032) Sem pdf conforme despacho.
PY - 2016
Y1 - 2016
N2 - Sucrose octa(N-ethyl)carbamate was synthesized directly from sucrose and ethyl isocyanate, and its structure was confirmed by various analytical methods, such as (1)H and (13)C NMR, FTIR, m.p., MS, and optical rotation. Its antibacterial, antifungal and cytotoxic activities were investigated. It exhibited strong inhibition against all bacteria tested, namely S. aureus (MIC 0.18±0.006), B. cereus (MIC 0.094±0.000), M. flavus (MIC 0.28±0.01), L. monocytogenes (MIC 0.18±0.006), P. aeruginosa (MIC 0.094±0.002), S. typhimurium (MIC 0.094±0.002), E. coli (MIC 0.18±0.006) and E. cloacae (MIC 0.18±0.006) and strong antifungal activity towards T. viride (MIC 0.09 ± 0.006), A. versicolor (MIC 0.18 ± 0.01), A. ochraceus (MIC 0.375 ± 0.01) and P. ochrochloron (MIC 0.375 ± 0.04). Furthermore, it showed moderate antitumor potential against human breast (GI50 357.20±14.12), colon (GI50 332.43±11.19) and cervical (GI50 282.67±3.97) cell lines and, more important, without hepatotoxicity.
AB - Sucrose octa(N-ethyl)carbamate was synthesized directly from sucrose and ethyl isocyanate, and its structure was confirmed by various analytical methods, such as (1)H and (13)C NMR, FTIR, m.p., MS, and optical rotation. Its antibacterial, antifungal and cytotoxic activities were investigated. It exhibited strong inhibition against all bacteria tested, namely S. aureus (MIC 0.18±0.006), B. cereus (MIC 0.094±0.000), M. flavus (MIC 0.28±0.01), L. monocytogenes (MIC 0.18±0.006), P. aeruginosa (MIC 0.094±0.002), S. typhimurium (MIC 0.094±0.002), E. coli (MIC 0.18±0.006) and E. cloacae (MIC 0.18±0.006) and strong antifungal activity towards T. viride (MIC 0.09 ± 0.006), A. versicolor (MIC 0.18 ± 0.01), A. ochraceus (MIC 0.375 ± 0.01) and P. ochrochloron (MIC 0.375 ± 0.04). Furthermore, it showed moderate antitumor potential against human breast (GI50 357.20±14.12), colon (GI50 332.43±11.19) and cervical (GI50 282.67±3.97) cell lines and, more important, without hepatotoxicity.
KW - Biological activity
KW - sucrose derivatization
U2 - 10.2174/1573406410666150807111029
DO - 10.2174/1573406410666150807111029
M3 - Article
VL - 12
SP - 22
EP - 29
JO - Journal Of Medicinal Chemistry
JF - Journal Of Medicinal Chemistry
SN - 0022-2623
IS - 1
ER -