Synthesis, Characterisation and Antiproliferative Studies of Allyl(dicarbonyl)(cyclopentadienyl)molybdenum Complexes and Cyclodextrin Inclusion Compounds

Susana S. Braga, Vijaya Mokal, Filipe A. Almeida Paz, Martyn Pillinger, Ana F. Branco, Vilma A. Sardao, Catia V. Diogo, Paulo J. Oliveira, Maria P. M. Marques, Carlos Jose Romao, Isabel S. Goncalves

Research output: Contribution to journalArticle

Abstract

The complexes [(eta(5)-C5H4-CO-R)Mo(CO)(2)(eta(3)-C3H5)] [R = OH (1), Phe OMe (2)] have been examined as guests for the cyclodextrin (CD) hosts beta-CD and heptakis(2,3,6-tri-O-methyl)-beta-CD (TRIMEB), and the resultant inclusion compounds have been characterised in the solid state by elemental and thermogravimetric analyses, powder X-ray diffraction, C-13{H-1) cross-polarisation (CP) magic angle spinning (MAS) NM R spectroscopy and ITTIR spectroscopy. Singlecrystal X-ray analysis of 1 shows that the unit cell contains centrosymmetric supramolecular dimers comprising two di- carlx)nyl complexes linked through hydrogen-bonding interactions involving the carboxylic acid groups. In screening tests for antiproliferative effects, the Cl) adducts containing 1 displayed enhanced antitumour activity against mouse melanoma (when compared with nonincluded 1), while showing minimal activity towards human adenocarcinoma and nontumour rat myoblast cell lines. TRIMEB encapsulation resulted in a predominant toxic effect on tumour cells versus the rion-neoplastic rriyoblasl cells.

Original languageEnglish
Pages (from-to)5034-5045
Number of pages12
JournalEuropean Journal of Inorganic Chemistry
Issue number29
DOIs
Publication statusPublished - Oct 2014

Keywords

  • Molybdenum
  • Half-sandwich complexes
  • Cyclodextrins
  • Inclusion compounds
  • Antitumor agents
  • ORGANOMETALLIC CONFORMATIONAL EQUILIBRIA
  • CAMBRIDGE STRUCTURAL DATABASE
  • RING INDENYL ANALOGS
  • BETA-CYCLODEXTRIN
  • CRYSTAL-STRUCTURES
  • ALLYL COMPLEXES
  • MIXED-RING
  • MOLYBDENUM COMPLEXES
  • CATALYST PRECURSORS
  • TUNGSTEN COMPLEXES

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