Synthesis and conformational analysis of 2,6-dimethyl-1,5-diaza-cis-decalins

Marisa C. Kozlowski, Zhenrong Xu, A. Gil Santos

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

The stereoselective synthesis of 2,6-dimethyl-1,5-diaza-cis-decalins with the dimethyl groups syn or anti to the angular hydrogens has been accomplished starting from 1,5-diaza-cis-decalin. From an NMR study of the conformational properties of all three 2,6-dimethyl-1,5-diaza-cis-decalins, the components which affect the conformational equilibrium have been identified.

Original languageEnglish
Pages (from-to)4537-4542
Number of pages6
JournalTetrahedron
Volume57
Issue number21
DOIs
Publication statusPublished - 21 May 2001

Keywords

  • Chiral diamine
  • Conformational switch
  • Diazadecalin

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