Synthesis and conformational analysis of 2,6-dimethyl-1,5-diaza-cis-decalins

Marisa C. Kozlowski; Zhenrong Xu; A. Gil Santos

doi:10.1016/S0040-4020(01)00370-2

Synthesis and conformational analysis of 2,6-dimethyl-1,5-diaza-cis-decalins

Marisa C. Kozlowski, Zhenrong Xu, A. Gil Santos

DQ - Departamento de Química

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

The stereoselective synthesis of 2,6-dimethyl-1,5-diaza-cis-decalins with the dimethyl groups syn or anti to the angular hydrogens has been accomplished starting from 1,5-diaza-cis-decalin. From an NMR study of the conformational properties of all three 2,6-dimethyl-1,5-diaza-cis-decalins, the components which affect the conformational equilibrium have been identified.

Original language	English
Pages (from-to)	4537-4542
Number of pages	6
Journal	Tetrahedron
Volume	57
Issue number	21
DOIs	https://doi.org/10.1016/S0040-4020(01)00370-2
Publication status	Published - 21 May 2001

Keywords

Chiral diamine
Conformational switch
Diazadecalin

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title = "Synthesis and conformational analysis of 2,6-dimethyl-1,5-diaza-cis-decalins",

abstract = "The stereoselective synthesis of 2,6-dimethyl-1,5-diaza-cis-decalins with the dimethyl groups syn or anti to the angular hydrogens has been accomplished starting from 1,5-diaza-cis-decalin. From an NMR study of the conformational properties of all three 2,6-dimethyl-1,5-diaza-cis-decalins, the components which affect the conformational equilibrium have been identified.",

keywords = "Chiral diamine, Conformational switch, Diazadecalin",

author = "Kozlowski, {Marisa C.} and Zhenrong Xu and Santos, {A. Gil}",

note = "Financial support for the research at the University of Pennsylvania was provided by the National Institutes of Health (GM59945), Merck Research Laboratories, DuPont, Pharmacia-Upjohn and the donors of the Petroleum Research Fund (administered by the American Chemical Society).",

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T1 - Synthesis and conformational analysis of 2,6-dimethyl-1,5-diaza-cis-decalins

AU - Kozlowski, Marisa C.

AU - Xu, Zhenrong

AU - Santos, A. Gil

N1 - Financial support for the research at the University of Pennsylvania was provided by the National Institutes of Health (GM59945), Merck Research Laboratories, DuPont, Pharmacia-Upjohn and the donors of the Petroleum Research Fund (administered by the American Chemical Society).

PY - 2001/5/21

Y1 - 2001/5/21

N2 - The stereoselective synthesis of 2,6-dimethyl-1,5-diaza-cis-decalins with the dimethyl groups syn or anti to the angular hydrogens has been accomplished starting from 1,5-diaza-cis-decalin. From an NMR study of the conformational properties of all three 2,6-dimethyl-1,5-diaza-cis-decalins, the components which affect the conformational equilibrium have been identified.

AB - The stereoselective synthesis of 2,6-dimethyl-1,5-diaza-cis-decalins with the dimethyl groups syn or anti to the angular hydrogens has been accomplished starting from 1,5-diaza-cis-decalin. From an NMR study of the conformational properties of all three 2,6-dimethyl-1,5-diaza-cis-decalins, the components which affect the conformational equilibrium have been identified.

KW - Chiral diamine

KW - Conformational switch

KW - Diazadecalin

UR - http://www.scopus.com/inward/record.url?scp=0035927234&partnerID=8YFLogxK

U2 - 10.1016/S0040-4020(01)00370-2

DO - 10.1016/S0040-4020(01)00370-2

M3 - Article

AN - SCOPUS:0035927234

VL - 57

SP - 4537

EP - 4542

JO - Tetrahedron

JF - Tetrahedron

SN - 0040-4020

IS - 21

ER -

Synthesis and conformational analysis of 2,6-dimethyl-1,5-diaza-cis-decalins

Abstract

Keywords

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