TY - JOUR
T1 - Synthesis and antimalarial properties of new chloro-9H-xanthones with an aminoaikyl side chain
AU - Portela, César
AU - Afonso, Carlos M.M.
AU - Pinto, Madalena M.M.
AU - Lopes, Dinora
AU - Nogueira, Fátima
AU - do Rosário, Vrigílio
PY - 2007
Y1 - 2007
N2 - The synthesis and antimalarial properties of twelve new chlorinated 9H-xanthones, carrying a [2-(diethylamino)ethyl]amino group in position 1, are reported. All compounds were found to be active towards the chloroquine-susceptible and chloroquine-resistant strains 3D7 and Dd2, resp., of the protozoa parasite Plasmodium falciparum. Especially one compound, 6-chloro-l-{[2-(diethylamino)-ethyl]amino}-gH-xanthen-9-one (1k), was found to exhibit significant in vitro activity (IC50=3.9 μM) towards the resistant Dd2 strain.
AB - The synthesis and antimalarial properties of twelve new chlorinated 9H-xanthones, carrying a [2-(diethylamino)ethyl]amino group in position 1, are reported. All compounds were found to be active towards the chloroquine-susceptible and chloroquine-resistant strains 3D7 and Dd2, resp., of the protozoa parasite Plasmodium falciparum. Especially one compound, 6-chloro-l-{[2-(diethylamino)-ethyl]amino}-gH-xanthen-9-one (1k), was found to exhibit significant in vitro activity (IC50=3.9 μM) towards the resistant Dd2 strain.
UR - http://www.scopus.com/inward/record.url?scp=34547553741&partnerID=8YFLogxK
U2 - 10.1002/cbdv.200790130
DO - 10.1002/cbdv.200790130
M3 - Article
C2 - 17638332
AN - SCOPUS:34547553741
SN - 1612-1872
VL - 4
SP - 1508
EP - 1519
JO - Chemistry and Biodiversity
JF - Chemistry and Biodiversity
IS - 7
ER -