Synthesis and antimalarial properties of new chloro-9H-xanthones with an aminoaikyl side chain

César Portela, Carlos M.M. Afonso, Madalena M.M. Pinto, Dinora Lopes, Fátima Nogueira, Vrigílio do Rosário

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14 Citations (Scopus)

Abstract

The synthesis and antimalarial properties of twelve new chlorinated 9H-xanthones, carrying a [2-(diethylamino)ethyl]amino group in position 1, are reported. All compounds were found to be active towards the chloroquine-susceptible and chloroquine-resistant strains 3D7 and Dd2, resp., of the protozoa parasite Plasmodium falciparum. Especially one compound, 6-chloro-l-{[2-(diethylamino)-ethyl]amino}-gH-xanthen-9-one (1k), was found to exhibit significant in vitro activity (IC50=3.9 μM) towards the resistant Dd2 strain.

Original languageEnglish
Pages (from-to)1508-1519
Number of pages12
JournalChemistry and Biodiversity
Volume4
Issue number7
DOIs
Publication statusPublished - 2007

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  • SDG 3 - Good Health and Well-Being

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