TY - JOUR
T1 - Sustainable synthesis of luminescent CdTe quantum dots coated with modified silica mesoporous nanoparticles: Towards new protein scavengers and smart drug delivery carriers
AU - Oliveira, Elisabete
AU - Santos, Hugo M.
AU - Jorge, Susana
AU - Rodríguez-González, Benito
AU - Novio, Fernando
AU - Lorenzo, Julia
AU - Ruiz-Molina, Daniel
AU - Capelo, José Luis
AU - Lodeiro, Carlos
N1 - info:eu-repo/grantAgreement/FCT/5876/147218/PT#
This work was supported by PROTEOMASS Scientific Society (Portugal) and LAQV/REQUIMTE (UID/QUI/50006/2013). D.R-M and F.N. want to thanks project MAT2015-70615-R from the Spanish Government and by FEDER funds. ICN2 acknowledges support from the Severo Ochoa Program (MINECO, Grant SEV-2013-0295). J. L acknowledges support from project BIO2016-08057-R from MINECO-Spain. EO and SJ acknowledge the Post-Doctoral and Doctoral grants SFRH/BPD/108660/2015 and SFRH/BD/120537/2016, respectively, from Fundacao para a Ciencia e a Tecnologia (FCT-MEC) Portugal. EO thanks to Foundation L'Oreal (UNESCO and FCT) for the Prize Women in Science 2015, "Medalhas de Honra L'Oreal Portugal para as Mulheres na Ciencia". We also thank to Ms. Jessica Ariana-Machado for her help in the physical characterization (IR studies). H.M.S. is funded by the FCT 2015 Investigator Program (IF/00007/2015).
PY - 2019/2/1
Y1 - 2019/2/1
N2 - The synthesis and full characterization of a family of sustainable luminescent nanoparticles, CdTeQDs@MNs, made of quantum dots coated by modified mesoporous silica nanoparticles is reported. The presence of the luminescent QDs allows the imaging of the nanoparticles during cell internalization, as well as the visualization of selective release of doxorubicin inside the cell (via pH stimuli). The modified mesoporous silica nanoparticles lead to pore size improvement allowing better encapsulation and controlled release, of different active principles studied such as, small molecules (rhodamine B), drugs (doxorubicin), and isolated proteins such as bovine serum albumin, lysozyme, carbonic anhydrase, ovalbumin, α-lactalbumin, hemoglobin, myoglobin and cytochrome C. Finally, and as a proof-of-concept the efficacy of these novel platforms was demonstrated through the successful extraction and recognition of proteins in raw serum of osteoarthritis and prosthesis patients, without any previous protein depletion.
AB - The synthesis and full characterization of a family of sustainable luminescent nanoparticles, CdTeQDs@MNs, made of quantum dots coated by modified mesoporous silica nanoparticles is reported. The presence of the luminescent QDs allows the imaging of the nanoparticles during cell internalization, as well as the visualization of selective release of doxorubicin inside the cell (via pH stimuli). The modified mesoporous silica nanoparticles lead to pore size improvement allowing better encapsulation and controlled release, of different active principles studied such as, small molecules (rhodamine B), drugs (doxorubicin), and isolated proteins such as bovine serum albumin, lysozyme, carbonic anhydrase, ovalbumin, α-lactalbumin, hemoglobin, myoglobin and cytochrome C. Finally, and as a proof-of-concept the efficacy of these novel platforms was demonstrated through the successful extraction and recognition of proteins in raw serum of osteoarthritis and prosthesis patients, without any previous protein depletion.
KW - Doxorubicin
KW - Luminescence
KW - Mesoporous silica nanoparticles
KW - Nanoproteomics
KW - Proteins
KW - Quantum dots
UR - http://www.scopus.com/inward/record.url?scp=85054176863&partnerID=8YFLogxK
U2 - 10.1016/j.dyepig.2018.09.047
DO - 10.1016/j.dyepig.2018.09.047
M3 - Article
AN - SCOPUS:85054176863
SN - 0143-7208
VL - 161
SP - 360
EP - 369
JO - Dyes and Pigments
JF - Dyes and Pigments
ER -