Surgical versus transcatheter aortic valve replacement in low-risk patients: A long-term propensity score-matched analysis

Catarina Brízido, Márcio Madeira, João Brito, Sérgio Madeira, Rui Campante Teles, Luís Raposo, Henrique Mesquita Gabriel, Tiago Nolasco, Pedro de Araújo Gonçalves, Miguel Sousa-Uva, Miguel Abecasis, Manuel de Sousa Almeida, José Pedro Neves, Miguel Mendes

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Recent studies suggest the use of transcatheter aortic valve implantation (TAVI) as an alternative to surgical aortic valve replacement (SAVR) in lower risk populations, but real-world data are scarce. Methods: Single-center retrospective study of patients undergoing SAVR (between June 2009 and July 2016, n = 682 patients) or TAVI (between June 2009 and July 2017, n = 400 patients). Low surgical risk was defined as EuroSCORE II (ES II) < 4% for single noncoronary artery bypass graft procedure. TAVI patients were propensity score-matched in a 1:1 ratio with SAVR patients, paired by age, New York Heart Association class, diabetes mellitus, chronic obstructive pulmonary disease, atrial fibrillation, creatinine clearance, and left ventricular ejection fraction < 50%. Results: A total of 158 patients (79 SAVR and 79 TAVI) were matched (mean age 79 ± 6 years, 79 men). TAVI patients had a higher incidence of permanent pacemaker implantation (0% vs. 19%, p < 0.001) and more than mild paravalvular leak (4% vs. 18%, p = 0.009), but comparable rates of stroke, major or life-threatening bleeding, emergent cardiac surgery, new-onset atrial fibrillation, and need for renal replacement therapy. Hospital length-of-stay and 30-day mortality were similar. At a median follow-up of 4.5 years (IQR 3.0–6.9), treatment strategy did not influence all-cause mortality (HR 1.19, 95% CI 0.77–1.83, log rank p = 0.43) nor rehospitalization (crude subdistribution HR 1.56, 95% CI 0.71–3.41, p = 0.26). ES II remained the only independent predictor of long-term all-cause mortality (adjusted HR 1.40, 95% CI 1.04–1.90, p = 0.029). Conclusion: In this low surgical risk severe aortic stenosis population, we observed similar rates of 30-day and long-term all-cause mortality, despite higher rates of permanent pacemaker implantation and more than mild paravalvular leak in TAVI patients. The results of this small study suggest that both procedures are safe and effective in the short-term, while the Heart Team remains essential to assess both options on the long-term.

Original languageEnglish
JournalCatheterization and Cardiovascular Interventions
DOIs
Publication statusE-pub ahead of print - 2021

Keywords

  • aortic valve disease
  • percutaneous intervention
  • surgery
  • transcatheter valve implantation
  • valvular

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