Superoxide dismutases and superoxide reductases

Yuewei Sheng, Isabel Alexandra Aguiar de Abreu, Diane E. Cabelli, Michael J. Maroney, Anne Frances Miller, Miguel Teixeira, Joan Selverstone Valentine

Research output: Contribution to journalReview articlepeer-review

410 Citations (Scopus)


A scientific review presents information about superoxide dismutases and superoxide reductases. The review reveals that the superoxide reductase (SOR) and three very different types of superoxide dismutase (SOD) enzymes are redox-active metalloenzymes that have evolved entirely independently from one another for the purpose of lowering superoxide concentrations. SODs catalyze the disproportionation of superoxide to give O2 and H2O 2, a reaction requiring one proton per superoxide reacted without external reductant. All of the SOR enzymes contain only iron, while the three types of SODs are the nickel-containing SODs (NiSOD), the iron- or manganese-containing SODs (FeSOD and MnSOD), and the copper- and zinc-containing SODs (CuZnSOD).

Original languageEnglish
Pages (from-to)3854-3918
Number of pages65
JournalChemical Reviews
Issue number7
Publication statusPublished - 9 Apr 2014


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