Supercritical fluid polymerisation and impregnation of molecularly imprinted polymers for drug delivery

Ana Rita C Duarte; Teresa Casimiro; Ana Aguiar-Ricardo; Ana Luísa Simplício; Catarina M. M. Duarte

doi:10.1016/j.supflu.2006.01.013

Supercritical fluid polymerisation and impregnation of molecularly imprinted polymers for drug delivery

Ana Rita C Duarte, Teresa Casimiro, Ana Aguiar-Ricardo, Ana Luísa Simplício, Catarina M. M. Duarte

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Abstract

Herein the preparation of molecularly imprinted polymers (MIPs) using supercritical fluid technology is evaluated. Poly(diethylene glycol dimethacrylate), polyDEGDMA, was synthesised in supercritical carbon dioxide (scCO₂) using a carboxylic acid end-capped perfluoropolyether oil as stabiliser. Polymerisations were carried out in the presence of different concentrations of two different template drug molecules, salicylic acid and acetylsalicylic acid. Results suggest that molecular imprinted polymers were successfully prepared by supercritical polymerisation and then impregnated with the template in order to prepare controlled release systems.

Original language	English
Pages (from-to)	102-106
Number of pages	5
Journal	Journal of Supercritical Fluids
Volume	39
Issue number	1
DOIs	https://doi.org/10.1016/j.supflu.2006.01.013
Publication status	Published - 1 Nov 2006

Keywords

Cross-linking
Diethylene glycol dimethacrylate
Impregnation
Molecular imprinting
Polymerisation
Supercritical carbon dioxide

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title = "Supercritical fluid polymerisation and impregnation of molecularly imprinted polymers for drug delivery",

abstract = "Herein the preparation of molecularly imprinted polymers (MIPs) using supercritical fluid technology is evaluated. Poly(diethylene glycol dimethacrylate), polyDEGDMA, was synthesised in supercritical carbon dioxide (scCO2) using a carboxylic acid end-capped perfluoropolyether oil as stabiliser. Polymerisations were carried out in the presence of different concentrations of two different template drug molecules, salicylic acid and acetylsalicylic acid. Results suggest that molecular imprinted polymers were successfully prepared by supercritical polymerisation and then impregnated with the template in order to prepare controlled release systems.",

keywords = "Cross-linking, Diethylene glycol dimethacrylate, Impregnation, Molecular imprinting, Polymerisation, Supercritical carbon dioxide",

author = "Duarte, {Ana Rita C} and Teresa Casimiro and Ana Aguiar-Ricardo and Simpl{\'i}cio, {Ana Lu{\'i}sa} and Duarte, {Catarina M. M.}",

note = "The authors gratefully acknowledge financial support from Funda{\c c}{\~a}o para a Ci{\^e}ncia e Tecnologia trough contracts POCTI/QUI/35429/2000, POCTI/EQU/47715/2002 and by FEDER and FSE. A.R.C. Duarte and T. Casimiro thank FCT/Lisbon for grants SFRH/BD/10780/2002 and SFRH/BPD/11665/2002, respectively.",

year = "2006",

month = nov,

day = "1",

doi = "10.1016/j.supflu.2006.01.013",

language = "English",

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journal = "Journal of Supercritical Fluids",

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T1 - Supercritical fluid polymerisation and impregnation of molecularly imprinted polymers for drug delivery

AU - Duarte, Ana Rita C

AU - Casimiro, Teresa

AU - Aguiar-Ricardo, Ana

AU - Simplício, Ana Luísa

AU - Duarte, Catarina M. M.

N1 - The authors gratefully acknowledge financial support from Fundação para a Ciência e Tecnologia trough contracts POCTI/QUI/35429/2000, POCTI/EQU/47715/2002 and by FEDER and FSE. A.R.C. Duarte and T. Casimiro thank FCT/Lisbon for grants SFRH/BD/10780/2002 and SFRH/BPD/11665/2002, respectively.

PY - 2006/11/1

Y1 - 2006/11/1

N2 - Herein the preparation of molecularly imprinted polymers (MIPs) using supercritical fluid technology is evaluated. Poly(diethylene glycol dimethacrylate), polyDEGDMA, was synthesised in supercritical carbon dioxide (scCO2) using a carboxylic acid end-capped perfluoropolyether oil as stabiliser. Polymerisations were carried out in the presence of different concentrations of two different template drug molecules, salicylic acid and acetylsalicylic acid. Results suggest that molecular imprinted polymers were successfully prepared by supercritical polymerisation and then impregnated with the template in order to prepare controlled release systems.

AB - Herein the preparation of molecularly imprinted polymers (MIPs) using supercritical fluid technology is evaluated. Poly(diethylene glycol dimethacrylate), polyDEGDMA, was synthesised in supercritical carbon dioxide (scCO2) using a carboxylic acid end-capped perfluoropolyether oil as stabiliser. Polymerisations were carried out in the presence of different concentrations of two different template drug molecules, salicylic acid and acetylsalicylic acid. Results suggest that molecular imprinted polymers were successfully prepared by supercritical polymerisation and then impregnated with the template in order to prepare controlled release systems.

KW - Cross-linking

KW - Diethylene glycol dimethacrylate

KW - Impregnation

KW - Molecular imprinting

KW - Polymerisation

KW - Supercritical carbon dioxide

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JO - Journal of Supercritical Fluids

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