TY - JOUR
T1 - Supercritical fluid polymerisation and impregnation of molecularly imprinted polymers for drug delivery
AU - Duarte, Ana Rita C
AU - Casimiro, Teresa
AU - Aguiar-Ricardo, Ana
AU - Simplício, Ana Luísa
AU - Duarte, Catarina M. M.
N1 - The authors gratefully acknowledge financial support from Fundação para a Ciência e Tecnologia trough contracts POCTI/QUI/35429/2000, POCTI/EQU/47715/2002 and by FEDER and FSE. A.R.C. Duarte and T. Casimiro thank FCT/Lisbon for grants SFRH/BD/10780/2002 and SFRH/BPD/11665/2002, respectively.
PY - 2006/11/1
Y1 - 2006/11/1
N2 - Herein the preparation of molecularly imprinted polymers (MIPs) using supercritical fluid technology is evaluated. Poly(diethylene glycol dimethacrylate), polyDEGDMA, was synthesised in supercritical carbon dioxide (scCO2) using a carboxylic acid end-capped perfluoropolyether oil as stabiliser. Polymerisations were carried out in the presence of different concentrations of two different template drug molecules, salicylic acid and acetylsalicylic acid. Results suggest that molecular imprinted polymers were successfully prepared by supercritical polymerisation and then impregnated with the template in order to prepare controlled release systems.
AB - Herein the preparation of molecularly imprinted polymers (MIPs) using supercritical fluid technology is evaluated. Poly(diethylene glycol dimethacrylate), polyDEGDMA, was synthesised in supercritical carbon dioxide (scCO2) using a carboxylic acid end-capped perfluoropolyether oil as stabiliser. Polymerisations were carried out in the presence of different concentrations of two different template drug molecules, salicylic acid and acetylsalicylic acid. Results suggest that molecular imprinted polymers were successfully prepared by supercritical polymerisation and then impregnated with the template in order to prepare controlled release systems.
KW - Cross-linking
KW - Diethylene glycol dimethacrylate
KW - Impregnation
KW - Molecular imprinting
KW - Polymerisation
KW - Supercritical carbon dioxide
UR - http://www.scopus.com/inward/record.url?scp=33751011600&partnerID=8YFLogxK
U2 - 10.1016/j.supflu.2006.01.013
DO - 10.1016/j.supflu.2006.01.013
M3 - Article
AN - SCOPUS:33751011600
SN - 0896-8446
VL - 39
SP - 102
EP - 106
JO - Journal of Supercritical Fluids
JF - Journal of Supercritical Fluids
IS - 1
ER -