Supercritical antisolvent precipitation of PHBV microparticles

Mariana Sousa Costa; Ana Rita Cruz  Duarte; Maria Margarida Canas Mendes de Almeida Cardoso; Catarina Maria Duarte

doi:10.1016/j.ijpharm.2006.08.004

Supercritical antisolvent precipitation of PHBV microparticles

Mariana Sousa Costa, Ana Rita Cruz Duarte, Maria Margarida Canas Mendes de Almeida Cardoso, Catarina Maria Duarte

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Abstract

The micronization of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) from organic solutions using supercritical antisolvent (SAS) technique has been successfully achieved. SAS experiments were carried out at different operational conditions and microspheres with mean diameters ranging from 3 to 9 mu m were obtained. The effect of CO2 and liquid flow, temperature and pressure on particle size and particle size distribution was evaluated. The microspheres were precipitated from a dichloromethane (DCM) solution. The best process conditions for this mixture were, according to our study, 40 degrees C, 100 bar, 1 mL min(-1) liquid flow and 10 L min(-1) carbon dioxide flow. Experiments with polymers containing different HV percentages were carried out. The powders obtained became more spherical as the HV content decreased. (c) 2006 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	72-77
Journal	International Journal of Pharmaceutics
Volume	328
Issue number	1
DOIs	https://doi.org/10.1016/j.ijpharm.2006.08.004
Publication status	Published - 2 Jan 2007

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Costa, M. S., Duarte, A. R. C., Cardoso, M. M. C. M. D. A., & Duarte, C. M. (2007). Supercritical antisolvent precipitation of PHBV microparticles. International Journal of Pharmaceutics, 328(1), 72-77. https://doi.org/10.1016/j.ijpharm.2006.08.004

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abstract = "The micronization of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) from organic solutions using supercritical antisolvent (SAS) technique has been successfully achieved. SAS experiments were carried out at different operational conditions and microspheres with mean diameters ranging from 3 to 9 mu m were obtained. The effect of CO2 and liquid flow, temperature and pressure on particle size and particle size distribution was evaluated. The microspheres were precipitated from a dichloromethane (DCM) solution. The best process conditions for this mixture were, according to our study, 40 degrees C, 100 bar, 1 mL min(-1) liquid flow and 10 L min(-1) carbon dioxide flow. Experiments with polymers containing different HV percentages were carried out. The powders obtained became more spherical as the HV content decreased. (c) 2006 Elsevier B.V. All rights reserved.",

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author = "Costa, {Mariana Sousa} and Duarte, {Ana Rita Cruz} and Cardoso, {Maria Margarida Canas Mendes de Almeida} and Duarte, {Catarina Maria}",

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AU - Cardoso, Maria Margarida Canas Mendes de Almeida

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AB - The micronization of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) from organic solutions using supercritical antisolvent (SAS) technique has been successfully achieved. SAS experiments were carried out at different operational conditions and microspheres with mean diameters ranging from 3 to 9 mu m were obtained. The effect of CO2 and liquid flow, temperature and pressure on particle size and particle size distribution was evaluated. The microspheres were precipitated from a dichloromethane (DCM) solution. The best process conditions for this mixture were, according to our study, 40 degrees C, 100 bar, 1 mL min(-1) liquid flow and 10 L min(-1) carbon dioxide flow. Experiments with polymers containing different HV percentages were carried out. The powders obtained became more spherical as the HV content decreased. (c) 2006 Elsevier B.V. All rights reserved.

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10.1016/j.ijpharm.2006.08.004