Studies on the preparation of 4-ethoxyalkyliden and 4-aminoalkyliden-5(4H)-oxazolones

Marta R. P. Norton Matos, Pedro M. P. Gois, Maria L. E. N. Mata, Eurico J. Cabrita, Carlos A. M. Afonso

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Optimized conditions for the preparation of 4-ethoxyalkyliden5(4H)-oxazolones were developed. A considerable steric hindrance was observed on the nucleophilic substitution of the ethoxy group by amines.

Original languageEnglish
Pages (from-to)1285-1299
Number of pages15
JournalSynthetic Communications
Issue number8
Publication statusPublished - 2003


  • 4-Aminoalkyliden-5(4H)-oxazolones
  • E/Z-configuration
  • Heterocycles
  • Nucleophilic substitution
  • Oxazolones


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