Studies on the formation and stability of perfluorodecalin nanoemulsions by ultrasound emulsification using novel surfactant systems

Usman Taqui Syed, Ana M. A. Dias, João Crespo, Carla Brazinha, Hermínio C. de Sousa

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Low-molecular weight perfluorocarbons (PFC) are suitable for therapeutic/biomedical applications involving O2/CO2/NO capture, transport and release (e.g., blood substitutes). However, PFC-in-Water emulsions face challenges related to inadequate emulsion stability, wide-sized droplet distribution and reduced shelf-life, which may be tackled by producing PFC-based nanoemulsions. A novel surfactant system comprising of Tween 80 and (1H,1H,2H,2H-perfluorooctyl)phosphocholine (FC8) was explored to produce monomodal narrow-sized distribution of PFC-in-Water nanoemulsions by ultrasound emulsification. Perfluorodecalin (PFD) was used as the model PFC. Surfactant solutions and emulsions were characterised for surface tension, interfacial tension and emulsion kinetic stability. In comparison to Tween 80, at 4.3 mM, the fluorinated FC8 surfactant-based emulsion droplets were 32 % smaller and six times more stable. Reduction of interfacial tension from 41.5 ± 0.5 mN.m−1 for Tween 80 alone to 20.7 ± 1.8 mN.m−1 for FC8 alone was related to better droplet size distribution of resultant emulsion, with a decrease in Zavg from 255.4 ± 3.9 nm to 172.8 ± 0.72 nm. Equimolar mixture of surfactants resulted in Zavg of 175.8 ± 1.1 nm at a reduced sonication time of 15 min, leading to safer surfactant system with lower energy and operating costs for emulsions preparation.

Original languageEnglish
Article number126315
JournalColloids and Surfaces A: Physicochemical and Engineering Aspects
Volume616
DOIs
Publication statusPublished - 5 May 2021

Keywords

  • Emulsion droplet size
  • Emulsion kinetic stability
  • Fluorinated surfactant systems
  • Perfluorodecalin-in-water nanoemulsions
  • Ultrasound emulsification

Fingerprint

Dive into the research topics of 'Studies on the formation and stability of perfluorodecalin nanoemulsions by ultrasound emulsification using novel surfactant systems'. Together they form a unique fingerprint.

Cite this