Studies in a co-infection murine model of Plasmodium chabaudi chabaudi and Leishmania infantum: interferon-gamma and interleukin-4 mRNA expression

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Abstract

This work aimed to study the T helper type 1/2 (Th1/Th2) cytokine profile in a co-infection murine model of Plasmodium chabaudi chabaudi and Leishmania infantum. Expression of interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) was analyzed, in spleen and liver of C57BL/6 mice, by reverse transcriptase-polymerase chain reaction. High levels of IFN-gamma expression did not prevent the progression of Leishmania in co-infected mice and Leishmania infection did not interfere with the Th1/Th2 switch necessary for Plasmodium control. The presence of IL-4 at day 28 in co-infected mice, essential for Plasmodium elimination, was probably a key factor on the exacerbation of the Leishmania infection.

Original languageEnglish
Pages (from-to)889-892
Number of pages4
JournalMemorias do Instituto Oswaldo Cruz
VolumeVol. 100
Issue numbern.º 8
DOIs
Publication statusPublished - Dec 2005

Keywords

  • Animals
  • Disease Models, Animal
  • Female
  • Interferon-gamma
  • Interleukin-4
  • Leishmania infantum
  • Leishmaniasis, Visceral
  • Liver
  • Malaria
  • Mice
  • Mice, Inbred C57BL
  • Parasitemia
  • Plasmodium chabaudi
  • RNA, Messenger
  • RNA, Protozoan
  • Reverse Transcriptase Polymerase Chain Reaction
  • Spleen
  • Th1 Cells
  • Th2 Cells
  • Journal Article

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