Structure, genetic regulation, physiology and function of the acrab-tolc efflux pump of escherichia coli and salmonella

Leonard Amaral, Ana Martins, Gabriella Spengler, Marta Martins, Liliana Rodrigues, Matthew McCusker, Eleni Ntokou, Pedro Cerca, Lisa Machado, Miguel Viveiros, Isabel Couto, Séamus Fanning, Jette Kristiansen, Joseph Molnar

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

This chapter reviews current knowledge on the structure and function of the AcrAb-TOlC efflux pump of Escherichia coli and Salmonella. Relevant effects of phenothiazines on the genes that regulate and encode this pump mechanism, as well as on the pump itself, are also described. Future perspectives in relation to this important efflux pump found in drug-resistant bacterial pathogens are discussed.
Original languageEnglish
Title of host publicationAntimicrobial drug discovery
Subtitle of host publication emerging strategies
EditorsA. Tegos, E. Mylonakis
PublisherCABI Publishing
Chapter4
Pages44-61
Number of pages18
ISBN (Print)9781845939434
Publication statusPublished - 31 Aug 2012

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