Structure, genetic regulation, physiology and function of the acrab-tolc efflux pump of escherichia coli and salmonella

Leonard Amaral; Ana Martins; Gabriella Spengler; Marta Martins; Liliana Rodrigues; Matthew McCusker; Eleni Ntokou; Pedro Cerca; Lisa Machado; Miguel Viveiros; Isabel Couto; Séamus Fanning; Jette Kristiansen; Joseph Molnar

Structure, genetic regulation, physiology and function of the acrab-tolc efflux pump of escherichia coli and salmonella

Leonard Amaral, Ana Martins, Gabriella Spengler, Marta Martins, Liliana Rodrigues, Matthew McCusker, Eleni Ntokou, Pedro Cerca, Lisa Machado, Miguel Viveiros, Isabel Couto, Séamus Fanning, Jette Kristiansen, Joseph Molnar

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Citation (Scopus)

Abstract

This chapter reviews current knowledge on the structure and function of the AcrAb-TOlC efflux pump of Escherichia coli and Salmonella. Relevant effects of phenothiazines on the genes that regulate and encode this pump mechanism, as well as on the pump itself, are also described. Future perspectives in relation to this important efflux pump found in drug-resistant bacterial pathogens are discussed.

Original language	English
Title of host publication	Antimicrobial drug discovery
Subtitle of host publication	emerging strategies
Editors	A. Tegos, E. Mylonakis
Publisher	CAB International (CABI)
Chapter	4
Pages	44-61
Number of pages	18
ISBN (Print)	9781845939434
Publication status	Published - 31 Aug 2012

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Amaral, L., Martins, A., Spengler, G., Martins, M., Rodrigues, L., McCusker, M., Ntokou, E., Cerca, P., Machado, L., Viveiros, M., Couto, I., Fanning, S., Kristiansen, J., & Molnar, J. (2012). Structure, genetic regulation, physiology and function of the acrab-tolc efflux pump of escherichia coli and salmonella. In A. Tegos, & E. Mylonakis (Eds.), Antimicrobial drug discovery: emerging strategies (pp. 44-61). CAB International (CABI).

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abstract = "This chapter reviews current knowledge on the structure and function of the AcrAb-TOlC efflux pump of Escherichia coli and Salmonella. Relevant effects of phenothiazines on the genes that regulate and encode this pump mechanism, as well as on the pump itself, are also described. Future perspectives in relation to this important efflux pump found in drug-resistant bacterial pathogens are discussed.",

author = "Leonard Amaral and Ana Martins and Gabriella Spengler and Marta Martins and Liliana Rodrigues and Matthew McCusker and Eleni Ntokou and Pedro Cerca and Lisa Machado and Miguel Viveiros and Isabel Couto and S{\'e}amus Fanning and Jette Kristiansen and Joseph Molnar",

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day = "31",

language = "English",

isbn = "9781845939434",

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editor = "A. Tegos and E. Mylonakis",

booktitle = "Antimicrobial drug discovery",

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Amaral, L , Martins, A, Spengler, G, Martins, M , Rodrigues, L, McCusker, M, Ntokou, E, Cerca, P, Machado, L, Viveiros, M , Couto, I, Fanning, S, Kristiansen, J & Molnar, J 2012, Structure, genetic regulation, physiology and function of the acrab-tolc efflux pump of escherichia coli and salmonella. in A Tegos & E Mylonakis (eds), Antimicrobial drug discovery: emerging strategies. CAB International (CABI), pp. 44-61.

Structure, genetic regulation, physiology and function of the acrab-tolc efflux pump of escherichia coli and salmonella. / Amaral, Leonard ; Martins, Ana; Spengler, Gabriella et al.
Antimicrobial drug discovery: emerging strategies. ed. / A. Tegos; E. Mylonakis. CAB International (CABI), 2012. p. 44-61.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

TY - CHAP

T1 - Structure, genetic regulation, physiology and function of the acrab-tolc efflux pump of escherichia coli and salmonella

AU - Amaral, Leonard

AU - Martins, Ana

AU - Spengler, Gabriella

AU - Martins, Marta

AU - Rodrigues, Liliana

AU - McCusker, Matthew

AU - Ntokou, Eleni

AU - Cerca, Pedro

AU - Machado, Lisa

AU - Viveiros, Miguel

AU - Couto, Isabel

AU - Fanning, Séamus

AU - Kristiansen, Jette

AU - Molnar, Joseph

PY - 2012/8/31

Y1 - 2012/8/31

N2 - This chapter reviews current knowledge on the structure and function of the AcrAb-TOlC efflux pump of Escherichia coli and Salmonella. Relevant effects of phenothiazines on the genes that regulate and encode this pump mechanism, as well as on the pump itself, are also described. Future perspectives in relation to this important efflux pump found in drug-resistant bacterial pathogens are discussed.

AB - This chapter reviews current knowledge on the structure and function of the AcrAb-TOlC efflux pump of Escherichia coli and Salmonella. Relevant effects of phenothiazines on the genes that regulate and encode this pump mechanism, as well as on the pump itself, are also described. Future perspectives in relation to this important efflux pump found in drug-resistant bacterial pathogens are discussed.

UR - http://www.scopus.com/inward/record.url?scp=84890186954&partnerID=8YFLogxK

UR - https://www.researchgate.net/publication/232736082_Structure_Genetic_Regulation_Physiology_and_Function_of_the_AcrAB-TolC_Efflux_Pump_of_Escherichia_coli_and_Salmonella

M3 - Chapter

AN - SCOPUS:84890186954

SN - 9781845939434

SP - 44

EP - 61

BT - Antimicrobial drug discovery

A2 - Tegos, A.

A2 - Mylonakis, E.

PB - CAB International (CABI)

ER -

Structure, genetic regulation, physiology and function of the acrab-tolc efflux pump of escherichia coli and salmonella

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