This chapter reviews current knowledge on the structure and function of the AcrAb-TOlC efflux pump of Escherichia coli and Salmonella. Relevant effects of phenothiazines on the genes that regulate and encode this pump mechanism, as well as on the pump itself, are also described. Future perspectives in relation to this important efflux pump found in drug-resistant bacterial pathogens are discussed.
|Title of host publication||Antimicrobial drug discovery|
|Subtitle of host publication||emerging strategies|
|Editors||A. Tegos, E. Mylonakis|
|Publisher||CAB International (CABI)|
|Number of pages||18|
|Publication status||Published - 31 Aug 2012|