Structure and function of the xanthine-oxidase family of molybdenum enzymes

M. J. Romao, R. Huber

Research output: Contribution to journalReview article

Abstract

This work gives an account of the recent achievements which have contributed towards the understanding of the structure and function of the xanthine oxidase family of enzymes-the molybdenum hydroxylases. It is based essentially on the crystallographic data of the aldehyde oxido-reductase from Desulfovibrio (D.) gigas, a member of that family, whose structure is described in detail. Comparisons are made, whenever appropriate, with spectroscopic, kinetic and model compound studies. Mechanistic implications of the crystal structure of the D. gigas enzyme are considered and extended to the xanthine oxidase family.
Original languageEnglish
Pages (from-to)69-95
JournalMETAL SITES IN PROTEINS AND MODELS
Volume90
Publication statusPublished - 1998

Keywords

  • hydroxylase
  • molybdoenzymes
  • molybdopterin
  • protein crystallography
  • xanthine oxidase

Cite this

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title = "Structure and function of the xanthine-oxidase family of molybdenum enzymes",
abstract = "This work gives an account of the recent achievements which have contributed towards the understanding of the structure and function of the xanthine oxidase family of enzymes-the molybdenum hydroxylases. It is based essentially on the crystallographic data of the aldehyde oxido-reductase from Desulfovibrio (D.) gigas, a member of that family, whose structure is described in detail. Comparisons are made, whenever appropriate, with spectroscopic, kinetic and model compound studies. Mechanistic implications of the crystal structure of the D. gigas enzyme are considered and extended to the xanthine oxidase family.",
keywords = "hydroxylase, molybdoenzymes, molybdopterin, protein crystallography, xanthine oxidase",
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Structure and function of the xanthine-oxidase family of molybdenum enzymes. / Romao, M. J.; Huber, R.

In: METAL SITES IN PROTEINS AND MODELS, Vol. 90, 1998, p. 69-95.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Structure and function of the xanthine-oxidase family of molybdenum enzymes

AU - Romao, M. J.

AU - Huber, R.

PY - 1998

Y1 - 1998

N2 - This work gives an account of the recent achievements which have contributed towards the understanding of the structure and function of the xanthine oxidase family of enzymes-the molybdenum hydroxylases. It is based essentially on the crystallographic data of the aldehyde oxido-reductase from Desulfovibrio (D.) gigas, a member of that family, whose structure is described in detail. Comparisons are made, whenever appropriate, with spectroscopic, kinetic and model compound studies. Mechanistic implications of the crystal structure of the D. gigas enzyme are considered and extended to the xanthine oxidase family.

AB - This work gives an account of the recent achievements which have contributed towards the understanding of the structure and function of the xanthine oxidase family of enzymes-the molybdenum hydroxylases. It is based essentially on the crystallographic data of the aldehyde oxido-reductase from Desulfovibrio (D.) gigas, a member of that family, whose structure is described in detail. Comparisons are made, whenever appropriate, with spectroscopic, kinetic and model compound studies. Mechanistic implications of the crystal structure of the D. gigas enzyme are considered and extended to the xanthine oxidase family.

KW - hydroxylase

KW - molybdoenzymes

KW - molybdopterin

KW - protein crystallography

KW - xanthine oxidase

M3 - Review article

VL - 90

SP - 69

EP - 95

JO - METAL SITES IN PROTEINS AND MODELS

JF - METAL SITES IN PROTEINS AND MODELS

SN - 0081-5993

ER -