Structure and function of molybdopterin containing enzymes

Maria João Romão, Jörg Knäblein, Robert Huber, José J. G. Moura

Research output: Contribution to journalArticlepeer-review

82 Citations (Scopus)


Molybdopterin containing enzymes are present in a wide range of living systems and have been known for several decades. However, only in the past two years have the first crystal structures been reported for this type of enzyme. This has represented a major breakthrough in this field. The enzymes share common structural features, but reveal different polypeptide folding topologies. In this review we give an account of the related spectroscopic information and the crystallographic results, with emphasis on structure- function studies.

Original languageEnglish
Pages (from-to)121-144
Number of pages24
JournalProgress in Biophysics and Molecular Biology
Issue number2-3
Publication statusPublished - 5 Sept 1997


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