Structure and Function of Human Matrix Metalloproteinases

Research output: Contribution to journalReview articlepeer-review

30 Citations (Scopus)

Abstract

The extracellular matrix (ECM) is a macromolecules network, in which the most abundant molecule is collagen. This protein in triple helical conformation is highly resistant to proteinases degradation, the only enzymes capable of degrading the collagen are matrix metalloproteinases (MMPs). This resistance and maintenance of collagen, and consequently of ECM, is involved in several biological processes and it must be strictly regulated by endogenous inhibitors (TIMPs). The deregulation of MMPs activity leads to development of numerous diseases. This review shows MMPs complexity.

Original languageEnglish
JournalCells
Volume9
Issue number5
DOIs
Publication statusPublished - 26 Apr 2020

Keywords

  • collagen
  • matrix metalloproteinases
  • TIMP

Fingerprint

Dive into the research topics of 'Structure and Function of Human Matrix Metalloproteinases'. Together they form a unique fingerprint.

Cite this