Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody

Javier MacÍas-León, Iris A. Bermejo, Alicia Asín, Ana García-García, Ismael Compañón, Ester Jiménez-Moreno, Helena Coelho, Vincenzo Mangini, Inês S. Albuquerque, Filipa Marcelo, Juan L. Asensio, Gonçalo J. L. Bernardes, Hiren J. Joshi, Roberto Fiammengo, Ola Blixt, Ramón Hurtado-Guerrero, Francisco Corzana

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The molecular basis of antibody 5E5, which recognizes the entire GalNAc unit as a primary epitope is disclosed. The antibody's contacts with the peptide are mostly limited to two residues, allowing it to show some degree of promiscuity. These findings open the door to the chemical design of peptide-mimetics for developing efficient anti-cancer vaccines and diagnostic tools. This journal is

Original languageEnglish
Pages (from-to)15137-15140
Number of pages4
JournalChemical Communications
Volume56
Issue number96
DOIs
Publication statusPublished - 14 Dec 2020

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