TY - JOUR
T1 - Structural aspects of a trimetallic Cu II derivative: cytotoxicity and anti-proliferative activity on human cancer cell lines
AU - Das, Kuheli
AU - Datta, Amitabha
AU - Massera, Chiara
AU - Roma-Rodrigues, Catarina
AU - Barroso, Mariana
AU - Baptista, Pedro V.
AU - Fernandes, Alexandra R.
N1 - info:eu-repo/grantAgreement/FCT/5876/147258/PT#
co-financed by the ERDF under the PT2020 Partnership Agreement (POCI-01-0145-FEDER-007728).
PY - 2019/4/3
Y1 - 2019/4/3
N2 - A trimetallic Cu II derivative, [Cu 3 (L) 2 (CF 3 COO) 2 ] (1) (where H 2 L = N,N′-bis(salicylidene)-1,3-propanediamine), was prepared and characterized. In 1, the two terminal Cu II ions are linked to the central Cu II by trifluoroacetato and doubly bridging phenoxido. Both the square-pyramidal and octahedral geometries are observed among two different Cu II centers in the linear arrangement of the trimetallic unit. Compound 1 is characterized by IR and UV-Vis spectra. Compound 1 has high cytotoxic activity in breast adenocarcinoma (MCF-7), colorectal carcinoma (HCT116) and particularly, in ovarian carcinoma (A2780) cell line compared to a lung adenocarcinoma cell line. The IC 50 in A2780 cells is 25 times lower than the respective value for normal human primary fibroblasts demonstrating 1 has higher cytotoxicity towards cancer cells. Additionally, combination of DOX with 1 induces a higher loss of HCT116 cell viability compared with each drug alone.
AB - A trimetallic Cu II derivative, [Cu 3 (L) 2 (CF 3 COO) 2 ] (1) (where H 2 L = N,N′-bis(salicylidene)-1,3-propanediamine), was prepared and characterized. In 1, the two terminal Cu II ions are linked to the central Cu II by trifluoroacetato and doubly bridging phenoxido. Both the square-pyramidal and octahedral geometries are observed among two different Cu II centers in the linear arrangement of the trimetallic unit. Compound 1 is characterized by IR and UV-Vis spectra. Compound 1 has high cytotoxic activity in breast adenocarcinoma (MCF-7), colorectal carcinoma (HCT116) and particularly, in ovarian carcinoma (A2780) cell line compared to a lung adenocarcinoma cell line. The IC 50 in A2780 cells is 25 times lower than the respective value for normal human primary fibroblasts demonstrating 1 has higher cytotoxicity towards cancer cells. Additionally, combination of DOX with 1 induces a higher loss of HCT116 cell viability compared with each drug alone.
KW - cancer cell lines
KW - Copper(II)
KW - cytotoxicity
KW - DOX
KW - trimetallic
UR - http://www.scopus.com/inward/record.url?scp=85065565968&partnerID=8YFLogxK
U2 - 10.1080/00958972.2019.1597973
DO - 10.1080/00958972.2019.1597973
M3 - Article
AN - SCOPUS:85065565968
SN - 0095-8972
VL - 72
SP - 920
EP - 940
JO - Journal of Coordination Chemistry
JF - Journal of Coordination Chemistry
IS - 5-7
ER -
