Structural aspects of a trimetallic Cu II derivative: cytotoxicity and anti-proliferative activity on human cancer cell lines

Kuheli Das, Amitabha Datta, Chiara Massera, Catarina Roma-Rodrigues, Mariana Barroso, Pedro V. Baptista, Alexandra R. Fernandes

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A trimetallic Cu II derivative, [Cu 3 (L) 2 (CF 3 COO) 2 ] (1) (where H 2 L = N,N′-bis(salicylidene)-1,3-propanediamine), was prepared and characterized. In 1, the two terminal Cu II ions are linked to the central Cu II by trifluoroacetato and doubly bridging phenoxido. Both the square-pyramidal and octahedral geometries are observed among two different Cu II centers in the linear arrangement of the trimetallic unit. Compound 1 is characterized by IR and UV-Vis spectra. Compound 1 has high cytotoxic activity in breast adenocarcinoma (MCF-7), colorectal carcinoma (HCT116) and particularly, in ovarian carcinoma (A2780) cell line compared to a lung adenocarcinoma cell line. The IC 50 in A2780 cells is 25 times lower than the respective value for normal human primary fibroblasts demonstrating 1 has higher cytotoxicity towards cancer cells. Additionally, combination of DOX with 1 induces a higher loss of HCT116 cell viability compared with each drug alone.

Original languageEnglish
Pages (from-to)920-940
Number of pages21
JournalJournal of Coordination Chemistry
Volume72
Issue number5-7
DOIs
Publication statusPublished - 3 Apr 2019

Keywords

  • cancer cell lines
  • Copper(II)
  • cytotoxicity
  • DOX
  • trimetallic

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