TY - JOUR
T1 - Streamlining model organisms facilities operation
T2 - The benefits of a unified management structure
AU - Rebelo, Manuel
AU - Bom, Joana
AU - Borges, Ana C.
AU - Marques, Rute
AU - Pereira, Marília
AU - Leocádio, Ana S.
AU - Vieira, Liliana
AU - Ribeiro, Ana
AU - Vale, Liliana
AU - Santos, Inês
AU - Crisóstomo, Sandra
AU - Nunes, Vera
AU - Franco, Maysa
AU - Vieira, Adérito
AU - Pinto, Pedro
AU - Machado, Ana R.
AU - Demengeot, Jocelyne
N1 - Funding Information:
On the international stage, in 1998, IGC joined the emerging European Mouse Mutant Archive (EMMA) consortium, funded by the European Union (EU), and assumed the role of the Portuguese node within the consortium. Subsequently, IGC established a platform dedicated to hosting Germ-Free mice and conducting axenization procedures for new strains. In 2005, IGC took on the leadership of the EMMA Axenic Service work-package, a responsibility that continues up to the present day. EMMA has since been incorporated into INFRAFRONTIER, the pan-European Research Infrastructure specializing in the systemic phenotyping, archiving and distribution of mouse disease models, also organizing several trainings and workshops. Through INFRAFRONTIER the IGC Mouse Facility has actively participated in and hosted more than 25 external research projects requiring mouse axenization. As a pre-requisite to developing state-of-the art projects and services, the structure and functional organization of animal facilities are crucial. INFRAFRONTIER worked on gathering information on building plans, concepts and workflows of several rodent research facilities and commercial breeders around the world to help institutions who are planning to construct new or upgrade existing facilities.
Funding Information:
This work was developed with the support of CONGENTO LISBOA-01-0145-FEDER-022170, co-financed by FCT (Portugal) and Lisboa2020, under the PORTUGAL2020 agreement (European Regional Development Fund). We express our gratitude to our dedicated team of caretakers, including L\u00E9vi Pires, Carla Almada, Cl\u00E1udia Gafaniz, Carine Santos, Marco Rocha, Jo\u00E3o Lopes, and Jo\u00E3o Mendes, for their unwavering commitment and crucial contributions to the efficient operation of the Mouse Facility. We would also like to thank Carlos Penha-Gon\u00E7alves and Nuno Pereira for their crucial work on veterinary services. Additionally, we extend our thanks to Cl\u00E1udia Campos for skilfully managing the Metabolic Service. Special appreciation is extended to Andr\u00E9 Barros for his helpful input on manuscript editing. Our acknowledgment also goes to all users of the Core Facility for their invaluable daily feedback. Furthermore, we recognize the IGC Technical and Scientific Support Teams, collaborators of the Model Organism, emphasizing the dedicated involvement from the Maintenance Unit.
Publisher Copyright:
© The Author(s) 2025.
PY - 2025/2
Y1 - 2025/2
N2 - This article is dedicated to elucidating and showcasing the concept of a unified Core Facility for laboratory animals within a research institute specialized in basic biology and biomedical research. In many research centres, animal facilities operate as autonomous entities. Here, we discuss that the centralization of all animal model units within a consolidated organizational framework offers a multitude of benefits in terms of communication with a variety of institutional stakeholders, including the Direction Board, Operational Logistics (Maintenance, Lab Operations and Safety Units), Procurement and Accounting Offices, Research Funding Affairs, Institutional Communication, and IT Units. This integrated approach facilitates the implementation of consistent policies and service pricing strategies. Moreover, it promotes staff flexibility across species, allows for responsiveness to evolving research dynamics, emergence of new scientific areas and infrastructure challenges. This concept also inspires technical advancement within the animal facilities, supports training in Laboratory Animal Science, stimulates the standardization of animal welfare practices, and instils a culture of care transversal to all animal models, ultimately enhancing overall animal welfare. This strategy facilitated the integration of non-vertebrate animals and plant models into the Core Facility. Despite significant differences from vertebrate models, this expansion presented advantages, such as incorporation of specialized staff into a larger organizational structure, offering them new opportunities for skill development and enhancing the overall flexibility of the Core Facility’s operations.
AB - This article is dedicated to elucidating and showcasing the concept of a unified Core Facility for laboratory animals within a research institute specialized in basic biology and biomedical research. In many research centres, animal facilities operate as autonomous entities. Here, we discuss that the centralization of all animal model units within a consolidated organizational framework offers a multitude of benefits in terms of communication with a variety of institutional stakeholders, including the Direction Board, Operational Logistics (Maintenance, Lab Operations and Safety Units), Procurement and Accounting Offices, Research Funding Affairs, Institutional Communication, and IT Units. This integrated approach facilitates the implementation of consistent policies and service pricing strategies. Moreover, it promotes staff flexibility across species, allows for responsiveness to evolving research dynamics, emergence of new scientific areas and infrastructure challenges. This concept also inspires technical advancement within the animal facilities, supports training in Laboratory Animal Science, stimulates the standardization of animal welfare practices, and instils a culture of care transversal to all animal models, ultimately enhancing overall animal welfare. This strategy facilitated the integration of non-vertebrate animals and plant models into the Core Facility. Despite significant differences from vertebrate models, this expansion presented advantages, such as incorporation of specialized staff into a larger organizational structure, offering them new opportunities for skill development and enhancing the overall flexibility of the Core Facility’s operations.
KW - Animal facilities
KW - animal model
KW - ethics and welfare
KW - gnotobiotechnology
KW - laboratory animal welfare
KW - organisms and models
KW - policy
KW - teaching and training
UR - https://www.scopus.com/pages/publications/105000016122
U2 - 10.1177/00236772241309744
DO - 10.1177/00236772241309744
M3 - Article
C2 - 40017410
AN - SCOPUS:105000016122
SN - 0023-6772
VL - 59
SP - 11
EP - 22
JO - LABORATORY ANIMALS
JF - LABORATORY ANIMALS
IS - 1
ER -