Stratification of ST-elevation myocardial infarction patients based on soluble CD40L longitudinal changes

Patrícia Napoleão; Luís B P Cabral; Mafalda Selas; Cláudia Freixo; Maria do Céu Monteiro; Maria Begoña Criado; Marina C. Costa; Francisco J. Enguita; Ana Maria Viegas-Crespo; Carlota Saldanha; Miguel Mota Carmo; Rui Cruz Ferreira; Teresa Pinheiro

doi:10.1016/j.trsl.2016.04.005

Stratification of ST-elevation myocardial infarction patients based on soluble CD40L longitudinal changes

Patrícia Napoleão, Luís B P Cabral, Mafalda Selas, Cláudia Freixo, Maria do Céu Monteiro, Maria Begoña Criado, Marina C. Costa, Francisco J. Enguita, Ana Maria Viegas-Crespo, Carlota Saldanha, Miguel Mota Carmo, Rui Cruz Ferreira, Teresa Pinheiro

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Involvement of soluble CD40 ligand (sCD40L) in thrombosis and inflammation on the context of coronary artery disease is currently being revised. In that perspective, we had studied the association of sCD40L with markers of platelet activation and markers of endothelial and vascular function. On that cohort, a stratification of patients with acute myocardial infarction (AMI) 1 month after percutaneous coronary intervention (PCI) was observed based on concentrations of sCD40L. The study intended to identify the groups of AMI patients with different profiles of sCD40L concentrations and verify how medication, clinical evolution, biochemical data, and markers of regulation of endothelial function at genetic (endothelial nitric oxide synthase polymorphisms) and post-transcriptional levels (circulating microRNAs) affect sCD40L serum levels. Lower quartiles of sCD40L (

Original language	English
Pages (from-to)	95-104
Journal	Translational Research
DOIs	https://doi.org/10.1016/j.trsl.2016.04.005
Publication status	Published - Oct 2016

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10.1016/j.trsl.2016.04.005

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Napoleão, P., Cabral, L. B. P., Selas, M., Freixo, C., Monteiro, M. D. C., Criado, M. B., Costa, M. C., Enguita, F. J., Viegas-Crespo, A. M., Saldanha, C., Carmo, M. M., Ferreira, R. C., & Pinheiro, T. (2016). Stratification of ST-elevation myocardial infarction patients based on soluble CD40L longitudinal changes. Translational Research, 95-104. https://doi.org/10.1016/j.trsl.2016.04.005

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title = "Stratification of ST-elevation myocardial infarction patients based on soluble CD40L longitudinal changes",

abstract = "Involvement of soluble CD40 ligand (sCD40L) in thrombosis and inflammation on the context of coronary artery disease is currently being revised. In that perspective, we had studied the association of sCD40L with markers of platelet activation and markers of endothelial and vascular function. On that cohort, a stratification of patients with acute myocardial infarction (AMI) 1 month after percutaneous coronary intervention (PCI) was observed based on concentrations of sCD40L. The study intended to identify the groups of AMI patients with different profiles of sCD40L concentrations and verify how medication, clinical evolution, biochemical data, and markers of regulation of endothelial function at genetic (endothelial nitric oxide synthase polymorphisms) and post-transcriptional levels (circulating microRNAs) affect sCD40L serum levels. Lower quartiles of sCD40L (",

author = "Patr{\'i}cia Napole{\~a}o and Cabral, \{Lu{\'i}s B P\} and Mafalda Selas and Cl{\'a}udia Freixo and Monteiro, \{Maria do C{\'e}u\} and Criado, \{Maria Bego{\~n}a\} and Costa, \{Marina C.\} and Enguita, \{Francisco J.\} and Viegas-Crespo, \{Ana Maria\} and Carlota Saldanha and Carmo, \{Miguel Mota\} and Ferreira, \{Rui Cruz\} and Teresa Pinheiro",

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doi = "10.1016/j.trsl.2016.04.005",

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AU - Napoleão, Patrícia

AU - Cabral, Luís B P

AU - Selas, Mafalda

AU - Freixo, Cláudia

AU - Monteiro, Maria do Céu

AU - Criado, Maria Begoña

AU - Costa, Marina C.

AU - Enguita, Francisco J.

AU - Viegas-Crespo, Ana Maria

AU - Saldanha, Carlota

AU - Carmo, Miguel Mota

AU - Ferreira, Rui Cruz

AU - Pinheiro, Teresa

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PY - 2016/10

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N2 - Involvement of soluble CD40 ligand (sCD40L) in thrombosis and inflammation on the context of coronary artery disease is currently being revised. In that perspective, we had studied the association of sCD40L with markers of platelet activation and markers of endothelial and vascular function. On that cohort, a stratification of patients with acute myocardial infarction (AMI) 1 month after percutaneous coronary intervention (PCI) was observed based on concentrations of sCD40L. The study intended to identify the groups of AMI patients with different profiles of sCD40L concentrations and verify how medication, clinical evolution, biochemical data, and markers of regulation of endothelial function at genetic (endothelial nitric oxide synthase polymorphisms) and post-transcriptional levels (circulating microRNAs) affect sCD40L serum levels. Lower quartiles of sCD40L (

AB - Involvement of soluble CD40 ligand (sCD40L) in thrombosis and inflammation on the context of coronary artery disease is currently being revised. In that perspective, we had studied the association of sCD40L with markers of platelet activation and markers of endothelial and vascular function. On that cohort, a stratification of patients with acute myocardial infarction (AMI) 1 month after percutaneous coronary intervention (PCI) was observed based on concentrations of sCD40L. The study intended to identify the groups of AMI patients with different profiles of sCD40L concentrations and verify how medication, clinical evolution, biochemical data, and markers of regulation of endothelial function at genetic (endothelial nitric oxide synthase polymorphisms) and post-transcriptional levels (circulating microRNAs) affect sCD40L serum levels. Lower quartiles of sCD40L (

UR - https://www.scopus.com/pages/publications/84973626872

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DO - 10.1016/j.trsl.2016.04.005

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AN - SCOPUS:84973626872

SN - 1931-5244

SP - 95

EP - 104

JO - Translational Research

JF - Translational Research

ER -

Stratification of ST-elevation myocardial infarction patients based on soluble CD40L longitudinal changes

Abstract

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