TY - JOUR
T1 - Stratification of ST-elevation myocardial infarction patients based on soluble CD40L longitudinal changes
AU - Napoleão, Patrícia
AU - Cabral, Luís B P
AU - Selas, Mafalda
AU - Freixo, Cláudia
AU - Monteiro, Maria do Céu
AU - Criado, Maria Begoña
AU - Costa, Marina C.
AU - Enguita, Francisco J.
AU - Viegas-Crespo, Ana Maria
AU - Saldanha, Carlota
AU - Carmo, Miguel Mota
AU - Ferreira, Rui Cruz
AU - Pinheiro, Teresa
N1 - PMID: 27172386
PY - 2016/10
Y1 - 2016/10
N2 - Involvement of soluble CD40 ligand (sCD40L) in thrombosis and inflammation on the context of coronary artery disease is currently being revised. In that perspective, we had studied the association of sCD40L with markers of platelet activation and markers of endothelial and vascular function. On that cohort, a stratification of patients with acute myocardial infarction (AMI) 1 month after percutaneous coronary intervention (PCI) was observed based on concentrations of sCD40L. The study intended to identify the groups of AMI patients with different profiles of sCD40L concentrations and verify how medication, clinical evolution, biochemical data, and markers of regulation of endothelial function at genetic (endothelial nitric oxide synthase polymorphisms) and post-transcriptional levels (circulating microRNAs) affect sCD40L serum levels. Lower quartiles of sCD40L (
AB - Involvement of soluble CD40 ligand (sCD40L) in thrombosis and inflammation on the context of coronary artery disease is currently being revised. In that perspective, we had studied the association of sCD40L with markers of platelet activation and markers of endothelial and vascular function. On that cohort, a stratification of patients with acute myocardial infarction (AMI) 1 month after percutaneous coronary intervention (PCI) was observed based on concentrations of sCD40L. The study intended to identify the groups of AMI patients with different profiles of sCD40L concentrations and verify how medication, clinical evolution, biochemical data, and markers of regulation of endothelial function at genetic (endothelial nitric oxide synthase polymorphisms) and post-transcriptional levels (circulating microRNAs) affect sCD40L serum levels. Lower quartiles of sCD40L (
UR - http://www.scopus.com/inward/record.url?scp=84973626872&partnerID=8YFLogxK
U2 - 10.1016/j.trsl.2016.04.005
DO - 10.1016/j.trsl.2016.04.005
M3 - Article
C2 - 27172386
AN - SCOPUS:84973626872
SN - 1931-5244
SP - 95
EP - 104
JO - Translational Research
JF - Translational Research
ER -
