Stratification of ST-elevation myocardial infarction patients based on soluble CD40L longitudinal changes

Patrícia Napoleão, Luís B P Cabral, Mafalda Selas, Cláudia Freixo, Maria do Céu Monteiro, Maria Begoña Criado, Marina C. Costa, Francisco J. Enguita, Ana Maria Viegas-Crespo, Carlota Saldanha, Miguel Mota Carmo, Rui Cruz Ferreira, Teresa Pinheiro

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Abstract

Involvement of soluble CD40 ligand (sCD40L) in thrombosis and inflammation on the context of coronary artery disease is currently being revised. In that perspective, we had studied the association of sCD40L with markers of platelet activation and markers of endothelial and vascular function. On that cohort, a stratification of patients with acute myocardial infarction (AMI) 1 month after percutaneous coronary intervention (PCI) was observed based on concentrations of sCD40L. The study intended to identify the groups of AMI patients with different profiles of sCD40L concentrations and verify how medication, clinical evolution, biochemical data, and markers of regulation of endothelial function at genetic (endothelial nitric oxide synthase polymorphisms) and post-transcriptional levels (circulating microRNAs) affect sCD40L serum levels. Lower quartiles of sCD40L (

Original languageEnglish
Pages (from-to)95
Number of pages104
JournalTranslational Research
DOIs
Publication statusPublished - Oct 2016

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    Napoleão, P., Cabral, L. B. P., Selas, M., Freixo, C., Monteiro, M. D. C., Criado, M. B., ... Pinheiro, T. (2016). Stratification of ST-elevation myocardial infarction patients based on soluble CD40L longitudinal changes. Translational Research, 95. https://doi.org/10.1016/j.trsl.2016.04.005