Stimuli-Responsive Glyconanomaterials for Sensing Applications

Carina I. C. Crucho, Maria Teresa Barros

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

6 Citations (Scopus)


Carbohydrates are ubiquitous in nature and intervene in a wide range of biological activities. They exhibit interesting properties such as low toxicity, biocompatibility, stability, low cost, hydrophilic nature, and availability of reactive sites for chemical modification. During the last decade, there have been many attempts to integrate carbohydrates in nanomaterials. In particular, smart glycopolymers have received remarkable attention due to their responsiveness to specific stimuli, making them promising candidates for more accurate and programmable drug delivery. Carbohydrate-based nanoparticles with pH, enzyme, magnetic, redox, and temperature-sensitive properties have been developed. In addition, sugar-based nanogels have also emerged as potential nanocarriers. Under this light, the state-of-the-art of stimuli-responsive glyconanoparticles will be covered. We highlight the design of tunable and versatile carbohydrate-based nanoparticles as targeted carriers with stimuli-triggered controlled and localized drug release. We hope this will stimulate the development of novel glyconanomedicines that are easier to handle, compatible with physiological media, and suitable for further clinical developments.

Original languageEnglish
Title of host publicationNanomaterials Design for Sensing Applications
Number of pages23
ISBN (Electronic)9780128145067
ISBN (Print)9780128145050
Publication statusPublished - 19 Mar 2019


  • Carbohydrates
  • Glyconanomaterials
  • Stimuli-responsive


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