TY - JOUR
T1 - Staphylococcus aureus in former Portuguese colonies from Africa and the Far East
T2 - Missing data to help fill the world map
AU - Conceição, T.
AU - Coelho, C.
AU - Santos Silva, I.
AU - de Lencastre, H.
AU - Aires-de-Sousa, M.
PY - 2015/9/1
Y1 - 2015/9/1
N2 - The aim of the present study was to determine the prevalence and risk factors for methicillin-resistant Staphylococcus aureus (MRSA) nasal carriage among patients and healthcare workers in Angola (ANG), São Tomé and Príncipe (STP), Cape Verde (CV) and East Timor (ET), and to characterize the antimicrobial susceptibility, virulence content and population structure of all S.aureus. Despite the importance of MRSA as a major human pathogen, data from these former Portuguese colonies in Africa and Asia are scarce. A total of 2065 nasal swabs recovered between 2010-14 were included in the study. Antimicrobial susceptibility testing and molecular characterization of S.aureus showed: (i) a very high MRSA prevalence in ANG (61.6%), moderate in STP (25.5%), low in CV (5.6%) and null in ET; (ii) a high prevalence of Panton-Valentine leukocidin in STP (36.8%), ET (29.2%) and CV (28.3%) contrasting with ANG (7.9%); (iii) ST5-SCC. mecIVa, ST8-IV/V and ST5-VI were the major MRSA clones in ANG (65.2%), STP (44.8%) and CV (50%), respectively; (iv) a high resistance to trimethoprim-sulfamethoxazole in ANG (66.5%) and STP (50.9%), to rifampin in ANG (77.3%), and to tetracycline in STP (26.3%) and ET (20.8%); (v) three major methicillin-susceptible S.aureus clones (ST15, ST508, ST152) were present in all four countries. Age
AB - The aim of the present study was to determine the prevalence and risk factors for methicillin-resistant Staphylococcus aureus (MRSA) nasal carriage among patients and healthcare workers in Angola (ANG), São Tomé and Príncipe (STP), Cape Verde (CV) and East Timor (ET), and to characterize the antimicrobial susceptibility, virulence content and population structure of all S.aureus. Despite the importance of MRSA as a major human pathogen, data from these former Portuguese colonies in Africa and Asia are scarce. A total of 2065 nasal swabs recovered between 2010-14 were included in the study. Antimicrobial susceptibility testing and molecular characterization of S.aureus showed: (i) a very high MRSA prevalence in ANG (61.6%), moderate in STP (25.5%), low in CV (5.6%) and null in ET; (ii) a high prevalence of Panton-Valentine leukocidin in STP (36.8%), ET (29.2%) and CV (28.3%) contrasting with ANG (7.9%); (iii) ST5-SCC. mecIVa, ST8-IV/V and ST5-VI were the major MRSA clones in ANG (65.2%), STP (44.8%) and CV (50%), respectively; (iv) a high resistance to trimethoprim-sulfamethoxazole in ANG (66.5%) and STP (50.9%), to rifampin in ANG (77.3%), and to tetracycline in STP (26.3%) and ET (20.8%); (v) three major methicillin-susceptible S.aureus clones (ST15, ST508, ST152) were present in all four countries. Age
KW - Africa
KW - Angola
KW - Cape Verde
KW - East Timor
KW - Far East
KW - Methicillin-resistant Staphylococcus aureus
KW - Nasal carriage
KW - Staphylococcus aureus
KW - São Tomé and Príncipe
UR - http://www.scopus.com/inward/record.url?scp=84940614801&partnerID=8YFLogxK
U2 - 10.1016/j.cmi.2015.05.010
DO - 10.1016/j.cmi.2015.05.010
M3 - Article
C2 - 26003281
AN - SCOPUS:84940614801
SN - 1198-743X
VL - 21
SP - 842.e1-842.e10
JO - Clinical Microbiology and Infection
JF - Clinical Microbiology and Infection
IS - 9
ER -
