TY - JOUR
T1 - Spread of the multiresistant iberian clone of methicillin-resistant Staphylococcus aureus (MRSA) to Italy and Scotland
AU - Mato, R.
AU - Santos Sanches, I.
AU - Venditti, M.
AU - Platt, D. J.
AU - Brown, A.
AU - Chung, M.
AU - De Lencastre, H.
PY - 1998/1/1
Y1 - 1998/1/1
N2 - The multidrug-resistant 'Iberian' clone of methicillin-resistant Staphylococcus aureus (MRSA) was first identified on the basis of its unique DNA fingerprints as the strain responsible for the massive 1989 outbreak of MRSA disease in the hospital Princeps d'Espanya, Barcelona, Spain. Most Iberian MRSA carry a constitutive β-lactamase. They are resistant to most β-lactam antibiotics, macrolides, aminoglycosides, tetracycline, rifampin and ciprofloxacin and are susceptible to fosfomycin, fusidic acid, mupirocin, sulfamethoxazole/trimethoprim and vancomycin. The characteristic DNA fingerprints of the clone include the mecA polymorph I, Tn554 pattern E (or its variants), a chromosomal macrorestriction pattern (pulsed-field gel electrophoretic type) A (or its subtype variants), the lack of the mecI regulatory gene and a homogeneous, high level of expression of methicillin resistance. Molecular surveillance studies have documented the extensive spread of this clone to many Portuguese hospitals during the 1990s. In this article, we describe the spread of the Iberian MRSA to hospitals in Rome, Italy, and Scotland.
AB - The multidrug-resistant 'Iberian' clone of methicillin-resistant Staphylococcus aureus (MRSA) was first identified on the basis of its unique DNA fingerprints as the strain responsible for the massive 1989 outbreak of MRSA disease in the hospital Princeps d'Espanya, Barcelona, Spain. Most Iberian MRSA carry a constitutive β-lactamase. They are resistant to most β-lactam antibiotics, macrolides, aminoglycosides, tetracycline, rifampin and ciprofloxacin and are susceptible to fosfomycin, fusidic acid, mupirocin, sulfamethoxazole/trimethoprim and vancomycin. The characteristic DNA fingerprints of the clone include the mecA polymorph I, Tn554 pattern E (or its variants), a chromosomal macrorestriction pattern (pulsed-field gel electrophoretic type) A (or its subtype variants), the lack of the mecI regulatory gene and a homogeneous, high level of expression of methicillin resistance. Molecular surveillance studies have documented the extensive spread of this clone to many Portuguese hospitals during the 1990s. In this article, we describe the spread of the Iberian MRSA to hospitals in Rome, Italy, and Scotland.
UR - http://www.scopus.com/inward/record.url?scp=0031748661&partnerID=8YFLogxK
U2 - 10.1089/mdr.1998.4.107
DO - 10.1089/mdr.1998.4.107
M3 - Article
C2 - 9650996
AN - SCOPUS:0031748661
SN - 1076-6294
VL - 4
SP - 107
EP - 112
JO - Microbial Drug Resistance
JF - Microbial Drug Resistance
IS - 2
ER -