TY - JOUR
T1 - Spread of a methicillin-resistant and multiresistant epidemic clone of Staphylococcus aureus in Argentina
AU - Corso, A.
AU - Sanches, I. Santos
AU - De Sousa, M. Aires
AU - Rossi, A.
AU - De Lencastre, H.
PY - 1998/1/1
Y1 - 1998/1/1
N2 - One hundred forty-eight recent methicillin-resistant Staphylococcus aureus (MRSA) isolates collected from 13 hospitals in Argentina were examined for antibiotic susceptibility and clonal type, using hybridization with DNA probes specific for mecA and Tn554, and pulsed-field gel electrophoresis (PFGE) of chromosomal SmaI digests. The majority of the isolates (62.2%) shared the common PFGE B pattern and carried variants of meca and Tn554 polymorphs characteristic of an MRSA clone widely spread in Brazilian hospitals. Similarly to the Brazilian isolates, the MRSA clone recovered in the Argentinian hospitals (XI::B::B) and its close relatives (XI::B'::B, XI::AA::B, XI::M::B, XI::ωω::B, and III::W::B) showed susceptibility to spectinomycin and resistance to numerous antibacterial agents, including β- lactams, tetracycline, aminoglycosides, macrolides, trimethoprim/sulfamethoxazole, ciprofloxacin, and fosfomycin, and more than 60% of the isolates were also resistant to chloramphenicol and rifampin. The XI::B::B MRSA clone represented the majority of isolates recovered in most of the hospitals, nine of which were located in the city of Buenos Aires, three in the province of Buenos Aires, and one in the province of Tucuman, 1,312 km northwest of the city of Buenos Aires. The observations document further geographic expansion of this South American MRSA clone across national boundaries.
AB - One hundred forty-eight recent methicillin-resistant Staphylococcus aureus (MRSA) isolates collected from 13 hospitals in Argentina were examined for antibiotic susceptibility and clonal type, using hybridization with DNA probes specific for mecA and Tn554, and pulsed-field gel electrophoresis (PFGE) of chromosomal SmaI digests. The majority of the isolates (62.2%) shared the common PFGE B pattern and carried variants of meca and Tn554 polymorphs characteristic of an MRSA clone widely spread in Brazilian hospitals. Similarly to the Brazilian isolates, the MRSA clone recovered in the Argentinian hospitals (XI::B::B) and its close relatives (XI::B'::B, XI::AA::B, XI::M::B, XI::ωω::B, and III::W::B) showed susceptibility to spectinomycin and resistance to numerous antibacterial agents, including β- lactams, tetracycline, aminoglycosides, macrolides, trimethoprim/sulfamethoxazole, ciprofloxacin, and fosfomycin, and more than 60% of the isolates were also resistant to chloramphenicol and rifampin. The XI::B::B MRSA clone represented the majority of isolates recovered in most of the hospitals, nine of which were located in the city of Buenos Aires, three in the province of Buenos Aires, and one in the province of Tucuman, 1,312 km northwest of the city of Buenos Aires. The observations document further geographic expansion of this South American MRSA clone across national boundaries.
UR - http://www.scopus.com/inward/record.url?scp=0032413539&partnerID=8YFLogxK
U2 - 10.1089/mdr.1998.4.277
DO - 10.1089/mdr.1998.4.277
M3 - Article
C2 - 9988046
AN - SCOPUS:0032413539
SN - 1076-6294
VL - 4
SP - 277
EP - 288
JO - Microbial Drug Resistance
JF - Microbial Drug Resistance
IS - 4
ER -