Solvent-Free and Catalysts-Free Chemistry: A Benign Pathway to Sustainability

Manoj B. Gawande, Vasco D. B. Bonifacio, Rafael Luque, Paula Cristina de Sério Branco, Rajender S. Varma

Research output: Contribution to journalLiterature review

175 Citations (Scopus)

Abstract

In the past decade, alternative benign organic methodologies have become an imperative part of organic syntheses and chemical reactions. The various new and innovative sustainable organic reactions and methodologies using no solvents or catalysts and employing alternative energy inputs such as microwaves, sonication, conventional and room temperature heating conditions, mechanochemical mixing, and high-speed ball milling are discussed in detail. Environmentally benign and pharmaceutically important reactions such as multicomponent, condensation, and Michael addition reactions; ring opening of epoxides; and oxidation and other significant organic reactions are discussed. An overview of benign reactions through solvent- and catalyst-free (SF-CF) chemistry and a critical perspective on emerging synergies between SF-CF organic reactions are discussed.

Original languageEnglish
Pages (from-to)24-44
Number of pages21
JournalChemSusChem
Volume7
Issue number1
DOIs
Publication statusPublished - Jan 2014

Keywords

  • catalyst-free
  • organic synthesis
  • reaction mechanisms
  • solvent-free
  • sustainable chemistry
  • ONE-POT SYNTHESIS
  • MICROWAVE-ASSISTED SYNTHESIS
  • DIELS-ALDER REACTIONS
  • FREE HETEROCYCLIC SYNTHESIS
  • TRANSITION-METAL-COMPLEXES
  • ALPHA-AMINO PHOSPHONATES
  • BAEYER-VILLIGER REACTION
  • FREE ORGANIC-SYNTHESIS
  • IONIC LIQUIDS
  • SOLID-STATE

Fingerprint Dive into the research topics of 'Solvent-Free and Catalysts-Free Chemistry: A Benign Pathway to Sustainability'. Together they form a unique fingerprint.

Cite this