Solution structures of tetrahaem ferricytochrome c(3) from Desulfovibrio vulgaris (Hildenborough) and its K45Q mutant: The molecular basis of cooperativity

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Abstract

The NMR structure of the oxidised wild-type cytochrome c(3) from Desulfovibrio vulgaris Hildenborough was determined in solution. Using a newly developed methodology, NMR data from the K45Q mutant was then grafted onto data from the wild-type protein to determine the structure in the region of the mutation. The structural origins of the redox-Bohr effect and haem-haem cooperativities are discussed with respect to the redox-related conformational changes observed in solution. (C) 2006 Elsevier B.V. All rights reserved.
Original languageUnknown
Pages (from-to)143-153
JournalBiochimica Et Biophysica Acta-Bioenergetics
Volume1757
Issue number2
DOIs
Publication statusPublished - 1 Jan 2006

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