Solubility of pharmaceutical compounds in ionic liquids

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51 Citations (Scopus)


The solubility of N-acetyl. l-cysteine, coumarin and 4-hydroxycoumarin in alternative solvents was studied in this work. The solid-liquid equilibrium (SLE) measurements have been performed using a dynamic (synthetic) method. Melting points and enthalpies of fusion of the pharmaceutical compounds were acquired using a differential scanning calorimetry (DSC). The solubility of N-acetyl. l-cysteine and 4-hydroxycoumarin in trifluoromethanesulfonate ionic liquids was found to be significantly higher than in the studied bis(trifluoromethylsulfonyl)amide ionic liquids while coumarin exhibited the opposite behaviour.The solid-liquid phase equilibria were described using the six different correlation equations which revealed a good description with an acceptable standard deviation temperature range.Moreover, the solubility data were used to calculate the 1-octanol/water partition coefficients of the studied drugs. Coumarin has a high partition coefficient, which is considered to be favourable for a rapid absorption of compounds once they are in an aqueous solution. N-acetyl. l-cysteine showed opposite results for the system with 1-octanol/water.

Original languageEnglish
Pages (from-to)18-29
Number of pages12
JournalFluid Phase Equilibria
Publication statusPublished - 25 Oct 2013


  • Ionic liquid
  • Partition coefficient
  • Solid-liquid equilibrium
  • Solubility
  • Thermochemical properties


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