Solubility of coenzyme Q10 in supercritical carbon dioxide

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Abstract

The equilibrium solubility of coenzyme Q10 (CoQ10) in supercritical carbon dioxide (scCO2) was measured by a static analytical method in the pressure range from 9 to 26 MPa, at temperatures of 305, 313 and 323 K. The cosolvent effect of ethanol in the solubility of the bioactive compound in scCO2 has been investigated, at 15 MPa and 313 K. A preliminary study of the viability of extracting CoQ10 with scCO2 has been investigated at 15 MPa and 313 K, using the content of commercial pharmaceutical capsules as the solid matrix feed. The solubility data results were correlated by use of the empirical density-based Chrastil model.

Original languageEnglish
Pages (from-to)201-206
Number of pages6
JournalJournal of Supercritical Fluids
Volume28
Issue number2-3
DOIs
Publication statusPublished - 1 Jan 2004

Keywords

  • Coenzyme Q10
  • Density-based correlation
  • Equilibrium solubility
  • Supercritical fluid extraction
  • Ubiquinone 50

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