TY - JOUR
T1 - Solubility of coenzyme Q10 in supercritical carbon dioxide
AU - Matias, Ana A.
AU - Nunes, Ana V. M.
AU - Casimiro, Teresa
AU - Duarte, Catarina M. M.
N1 - The authors thank Professor M. Nunes da Ponte and Professor Ana Aguiar-Ricardo for helpful suggestions and discussions. Catarina M.M. Duarte is grateful for financial support from JD (CC/100/FCT/00) grant .
PY - 2004/1/1
Y1 - 2004/1/1
N2 - The equilibrium solubility of coenzyme Q10 (CoQ10) in supercritical carbon dioxide (scCO2) was measured by a static analytical method in the pressure range from 9 to 26 MPa, at temperatures of 305, 313 and 323 K. The cosolvent effect of ethanol in the solubility of the bioactive compound in scCO2 has been investigated, at 15 MPa and 313 K. A preliminary study of the viability of extracting CoQ10 with scCO2 has been investigated at 15 MPa and 313 K, using the content of commercial pharmaceutical capsules as the solid matrix feed. The solubility data results were correlated by use of the empirical density-based Chrastil model.
AB - The equilibrium solubility of coenzyme Q10 (CoQ10) in supercritical carbon dioxide (scCO2) was measured by a static analytical method in the pressure range from 9 to 26 MPa, at temperatures of 305, 313 and 323 K. The cosolvent effect of ethanol in the solubility of the bioactive compound in scCO2 has been investigated, at 15 MPa and 313 K. A preliminary study of the viability of extracting CoQ10 with scCO2 has been investigated at 15 MPa and 313 K, using the content of commercial pharmaceutical capsules as the solid matrix feed. The solubility data results were correlated by use of the empirical density-based Chrastil model.
KW - Coenzyme Q10
KW - Density-based correlation
KW - Equilibrium solubility
KW - Supercritical fluid extraction
KW - Ubiquinone 50
UR - http://www.scopus.com/inward/record.url?scp=1642435792&partnerID=8YFLogxK
U2 - 10.1016/S0896-8446(03)00038-X
DO - 10.1016/S0896-8446(03)00038-X
M3 - Article
AN - SCOPUS:1642435792
SN - 0896-8446
VL - 28
SP - 201
EP - 206
JO - Journal of Supercritical Fluids
JF - Journal of Supercritical Fluids
IS - 2-3
ER -